Johanna M. Huusko

Learn More
Preterm birth is the major cause of neonatal mortality and morbidity. In many cases, it has severe life-long consequences for the health and neurological development of the newborn child. More than 50% of all preterm births are spontaneous, and currently there is no effective prevention. Several studies suggest that genetic factors play a role in(More)
Spontaneous preterm birth (SPTB) is a major factor associating with deaths and with lowered quality of life in humans. Environmental and genetic factors influence the susceptibility. Previously, by analyzing families with recurrent SPTB in linkage analysis, we identified a linkage peak close to the gene encoding CXCR3. Present objectives were to investigate(More)
RATIONALE Bronchopulmonary dysplasia is the most common chronic respiratory disease in premature infants. Genetic factors might contribute to bronchopulmonary dysplasia susceptibility. OBJECTIVES To identify genetic variants involved in bronchopulmonary dysplasia through a genome-wide association study. METHODS We prospectively evaluated 418 premature(More)
Background: Preterm birth accounts for 2-3 million annual deaths worldwide and is the major cause of acute and chronic morbidity in children. More than 50% of preterm births have a spontaneous onset. Family studies suggest that genetic factors affect the risk of spontaneous preterm birth (SPTB). However, the genetic background is poorly known.Aim: To search(More)
Introduction:Preterm birth is the major cause of mortality and morbidity in neonates. Intrauterine infection and/or inflammatory response are evident in 60–70% of spontaneous preterm births (SPTBs). Genetic factors significantly increase this risk. However, the genetic background associated with SPTB is poorly understood. Surfactant protein (SP) A, SP-D,(More)
Bronchopulmonary dysplasia (BPD) is a common chronic lung disease associated with very preterm birth. The major risk factors include lung inflammation and lung immaturity. In addition, genetic factors play an important role in susceptibility to moderate-to-severe BPD. In this study, the aim was to investigate whether common polymorphisms of specific genes(More)
BACKGROUND Prematurity and hereditary factors predispose to cerebral palsy (CP). Previously, low cord blood levels of the anti-inflammatory chemokine CCL18 have been found to be associated with risk of CP in preterm children. OBJECTIVES To investigate the association between single nucleotide polymorphisms (SNPs) in CCL18 and susceptibility to CP, as well(More)
Backgroung: Surfactant protein B (SP-B) is essential for normal lung function. Differences in SP-B levels may be influenced by variation in the encoding gene (SFTPB). SFTPB SNP Ile131Thr affects proSP-B N-terminal glycosylation.Aims: To investigate whether proSP-B glycosylation affects propeptide processing and secretion kinetics, and to determine whether(More)
Bronchopulmonary dysplasia (BPD), the main consequence of prematurity, has a significant heritability, but little is known about predisposing genes. The aim of this study was to identify gene loci predisposing infants to BPD. The initial genome-wide association study (GWAS) included 174 Finnish preterm infants of gestational age 24-30 weeks. Thereafter, the(More)