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Platelets from patients with diabetes are hyperreactive and demonstrate increased adhesiveness, aggregation, degranulation, and thrombus formation, processes that contribute to the accelerated development of vascular disease. Part of the problem seems to be dysregulated platelet Ca(2+) signaling and the activation of calpains, which are Ca(2+)-activated(More)
AIMS The reaction of nitric oxide and nitrite-derived species with polyunsaturated fatty acids yields electrophilic fatty acid nitroalkene derivatives (NO2-FA), which display anti-inflammatory properties. Given that the 5-lipoxygenase (5-LO, ALOX5) possesses critical nucleophilic amino acids, which are potentially sensitive to electrophilic modifications,(More)
The adenosine monophosphate (AMP)-activated protein kinase (AMPK) is a regulator of energy balance at the cellular and whole-body levels, but little is known about the role of AMPK in platelet activation. We report that both the α1 and α2 AMPK isoforms are expressed by human and murine platelets and that thrombin elicits the phosphorylation of AMPKα as well(More)
The decay time of CsI(Tl) scintillating material consists of more than a single exponential component. The ratio between the intensity of these components varies as a function of the ionizing power of the absorbed particles, such as γ-rays or protons, and the temperature. This property can therefore be used for particle discrimination and for(More)
The adenosine monophosphate (AMP)– activated protein kinase (AMPK) is a regulator of energy balance at the cellular and whole-body levels, but little is known about the role of AMPK in platelet activation. We report that both the 1 and 2 AMPK isoforms are expressed by human and murine platelets and that thrombin elicits the phosphorylation of AMPK as well(More)
The robot is becoming more and more part of the normal life that emerged some conflicts, like: How could a safe physical human robot interaction happen and what kind of problems had to be solved for a successful interaction? This paper describes a scenario of interactions between human and robots and it pointed out the improvement of the robot motion using(More)
In this paper we describe how a robotic arm can acquire new skills, and specifically how to play beer pong. We used two different optimization algorithms are described and applied to teach a robot how to play the game beer pong. The first algorithm is the gradient based finite difference method. The second one is the expectation maximization algorithm(More)
The E2/M1 multipole mixing ratio δ_{1→2} of the 1_{sc}^{+}→2_{1}^{+} γ-ray decay in ^{156}Gd and hence the isovector E2 transition rate of the scissors mode of a well-deformed rotational nucleus has been measured for the first time. It has been obtained from the angular distribution of an artificial quasimonochromatic linearly polarized γ-ray beam of energy(More)
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