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Twenty-three strains of herpes simplex virus type 1 were compared for their pathogenicity in 4-week-old BALB/c mice after peripheral (footpad) or intracerebral inoculation. Among those strains examined were (i) six clinical isolates of brain or cerebrospinal fluid origin, (ii) seven clinical isolates of oral or genital origin, (iii) five prototype(More)
Herpes simplex virus (HSV) is known to establish latency in human trigeminal ganglia. It has been speculated that the virus might also be present in latent fashion in normal human brain, where it might be responsible for conditions such as herpes simplex encephalitis, and less plausibly as a cause for multiple sclerosis or Alzheimer's disease. To test the(More)
Both tubular and spherical densities have been described in postsynaptic processes of mice with clinical scrapie. To determine whether the tubular appearances resulted from tubular structures or from overlap of spherical particles, electron microscopic examination was performed by tilting the specimen through large angles. In every instance where such could(More)
Between 1985 and 1990, there were 275 orthotopic cardiac transplantations performed on 263 patients. To determine the frequency and define the clinical spectrum of cerebrovascular disease among these patients, we followed them over an average period of 18.5 months (range, 1 to 59 months). Cerebrovascular disorders developed in 24 of 263 patients. We(More)
The effects of methylprednisolone sodium succinate and cytarabine have been examined in an experimental herpes simplex virus-induced encephalitis in rabbits. In this model herpes simplex virus (HSV) is normally cleared from the brains of untreated animals. Infected animals treated with large doses of methylprednisolone showed a slight delay in the rate of(More)
Sural nerve biopsy was performed on a six-year-old girl with a slowly progressive distal mixed polyneuropathy. The nerve fiber population was reduced, and of those remaining, approximately half were greatly enlarged, measuring up to 35 microns in cross section. Longitudinal sections showed axonal enlargement to be segmental. Ultrastructurally, swollen(More)