Johan Wallin

Bengt Linderoth4
Björn A Meyerson3
Gastón Schechtmann2
Jian-Guo Cui1
4Bengt Linderoth
3Björn A Meyerson
2Gastón Schechtmann
1Jian-Guo Cui
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Spinal cord stimulation (SCS) may provide pain relief in approximately 60%-70% of well selected patients with pain caused by peripheral nerve injury. We have previously demonstrated that intrathecal (IT) administration of small doses of certain drugs, both in experimental animals and in patients, significantly enhances the pain-relieving effect of SCS. The(More)
Substantial evidence has established that activation of the NMDA receptor in the spinal dorsal horn is essential for central sensitization-a phenomenon which comprises various pathophysiological mechanisms underlying neuropathic pain-like signs in animal models. In the present study, a partial sciatic nerve ligation in the rat was used to produce a model of(More)
Spinal cord stimulation (SCS) is an effective tool in alleviating neuropathic pain. However, a number of well-selected patients fail to obtain satisfactory pain relief. Previous studies have demonstrated that i.t. baclofen and/or adenosine can enhance the SCS effect, but this combined therapy has been shown to be useful in less than half of the cases and(More)
It has been suggested that long-term potentiation (LTP) of dorsal horn neurons is a phenomenon that contributes to the development of chronic neuropathic pain. Spinal cord stimulation (SCS) may be an effective tool in alleviating such pain. The aim of this electrophysiological study in rats was to examine if SCS suppresses LTP of dorsal horn wide dynamic(More)
The health care systems in the western democracies face today problems that relate to the implementation systems in the field of health policies. Knowledge management is important since it is the prerequisite for planning and implementing more intelligent health policies and practices. Updated conceptualization of knowledge management theory is a(More)
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