Johan T. Ruud

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Obesity and resistance to insulin are closely associated with the development of low-grade inflammation. Interleukin 6 (IL-6) is linked to obesity-associated inflammation; however, its role in this context remains controversial. Here we found that mice with an inactivated gene encoding the IL-6Rα chain of the receptor for IL-6 in myeloid cells (Il6ra(Δmyel)(More)
Activation of Agouti-related peptide (AgRP) neurons potently promotes feeding, and chronically altering their activity also affects peripheral glucose homeostasis. We demonstrate that acute activation of AgRP neurons causes insulin resistance through impairment of insulin-stimulated glucose uptake into brown adipose tissue (BAT). AgRP neuron activation(More)
Melanin-concentrating-hormone (MCH)-expressing neurons (MCH neurons) in the lateral hypothalamus (LH) are critical regulators of energy and glucose homeostasis. Here, we demonstrate that insulin increases the excitability of these neurons in control mice. In vivo, insulin promotes phosphatidylinositol 3-kinase (PI3K) signaling in MCH neurons, and(More)
M ore than one third of the adult population is obese in many countries, including newly industrialized states, making obesity a global human health problem1. Obesity is often accompanied by insulin resistance (the condition when cells fail to respond to insulin) and glucose intolerance (the inability of cells to clear glucose from the blood stream after a(More)
Cutting-edge experiments show a new means to control the activity of specifically genetically targeted neurons in the hypothalamus using electromagnetic force. At the flip of a switch, the system bidirectionally regulates feeding behavior and glucose homeostasis, demonstrating wireless control over deep brain regions and their strong influence over energy(More)
Der Oslofjord erstreckt sich etwa 100 km in nördlicher Richtung vom Skagerrak bis nach Oslo. Bei Drøbak, etwa auf dem zweiten Drittel des Weges nach Oslo, gibt es eine Reihe von Hindernissen, die einem ungehinderten Austausch der Wassermassen im Fjord entgegenstehen. Der wichtigste Durchlaß ist nur etwa 300 m breit und hat eine Wassertiefe über der Schwelle(More)