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Continuously indexed Gaussian fields (GFs) are the most important ingredient in spatial statistical modelling and geostatistics. The specification through the covariance function gives an intuitive interpretation of the field properties. On the computational side, GFs are hampered with the big n problem, since the cost of factorizing dense matrices is cubic(More)
Continuously indexed Gaussian fields (GFs) is the most important ingredient in spatial statistical modelling and geo-statistics. The specification through the covariance function gives an intuitive interpretation of its properties. On the computational side, GFs are hampered with the big-n problem, since the cost of factorising dense matrices is cubic in(More)
BACKGROUND: Epidemiological studies that assess the health effects of long-term exposure to ambient air pollution are used to inform public policy. These studies rely on exposure models that use data collected from pollution monitoring sites to predict exposures at subject locations. Land use regression (LUR) and universal kriging (UK) have been suggested(More)
We analyze the performance of a novel human tracking system, which uses the electric near field to sense human presence. The positioning accuracy with moving targets is measured using raw observations, observation centroids and Kalman filtered centroids. In addition to this, the multi-target discrimination performance is studied with two people and a(More)
A novel approach to background/foreground segmentation using an online EM algorithm is presented. The method models each layer as a Gaussian mixture, with local, per pixel, parameters for the background layer and global parameters for the foreground layer, utilising information from the entire scene when estimating the foreground. Additionally, the online(More)
AIMS To collect information on the use of the Reveal implantable loop recorder (ILR) in the patient care pathway and to investigate its effectiveness in the diagnosis of unexplained recurrent syncope in everyday clinical practice. METHODS AND RESULTS Prospective, multicentre, observational study conducted in 2006-2009 in 10 European countries and Israel.(More)
This study investigated the expression of ion transporters involved in intestinal fluid absorption and presents evidence for developmental changes in abundance and tissue distribution of these transporters during smoltification and seawater (SW) acclimation of Atlantic salmon Salmo salar. Emphasis was placed on Na(+) , K(+) -ATPase (NKA) and Na(+) , K(+) ,(More)
Amino-2H-imidazoles are described as a new class of BACE-1 inhibitors for the treatment of Alzheimer's disease. Synthetic methods, crystal structures, and structure-activity relationships for target activity, permeability, and hERG activity are reported and discussed. Compound (S)-1m was one of the most promising compounds in this report, with high potency(More)
The evaluation of a series of aminoisoindoles as β-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitors and the discovery of a clinical candidate drug for Alzheimer's disease, (S)-32 (AZD3839), are described. The improvement in permeability properties by the introduction of fluorine adjacent to the amidine moiety, resulting in in vivo brain(More)
BACKGROUND Cohort studies of the relationship between air pollution exposure and chronic health effects require predictions of exposure over long periods of time. OBJECTIVES We developed a unified modeling approach for predicting fine particulate matter, nitrogen dioxide, oxides of nitrogen, and black carbon (as measured by light absorption coefficient)(More)