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Eph tyrosine kinase receptors and their membrane-bound ephrin ligands mediate cell interactions and participate in several developmental processes. Ligand binding to an Eph receptor results in tyrosine phosphorylation of the kinase domain, and repulsion of axonal growth cones and migrating cells. Here we report that a subpopulation of ephrin-A5 null mice(More)
The number of cells in an organ is regulated by mitogens and trophic factors that impinge on intrinsic determinants of proliferation and apoptosis. We here report the identification of an additional mechanism to control cell number in the brain: EphA7 induces ephrin-A2 reverse signaling, which negatively regulates neural progenitor cell proliferation. Cells(More)
More than 10(10) cells are generated every day in the human intestine. Wnt proteins are key regulators of proliferation and are known endogenous mitogens for intestinal progenitor cells. The positioning of cells within the stem cell niche in the intestinal epithelium is controlled by B subclass ephrins through their interaction with EphB receptors. We(More)
Neuronal migration is a prerequisite event for the establishment of highly ordered neuronal circuits in the developing brain. Here, we report Pax6-dependent alignment of the olfactory cortex neurons in the developing telencephalon. These neurons were generated in the dorsal part of telencephalon, migrated ventrally and stopped at the pallium-subpallium(More)
The presence of stem cell characteristics in glioma cells raises the possibility that mechanisms promoting the maintenance and self-renewal of tissue specific stem cells have a similar function in tumor cells. Here we characterized human gliomas of various malignancy grades for the expression of stem cell regulatory proteins. We show that cells in high(More)
In recent years, it has become evident that neural stem cells in the adult mammalian brain continuously generate new neurons, mainly in the hippocampus and olfactory bulb. Although different growth factors have been shown to stimulate neurogenesis in the adult brain, very little is known about the role of neuropeptides in this process. Pituitary adenylate(More)
We determine the velocity distribution and space density of a volume complete sample of A and F stars, using parallaxes and proper motions from the Hipparcos satellite. We use these data to solve for the gravitational potential vertically in the local Galactic disc, by comparing the Hipparcos measured space density with predictions from various disc models.(More)
  • Chris Flynn, Johan Holmberg, Laura Portinari, Burkhard Fuchs, Hartmut Jahreiß
  • 2006
We measure the volume luminosity density and surface luminosity density generated by the Galactic disc, using accurate data on the local luminosity function and the disc's vertical structure. From the well measured volume mass density and surface mass density, we derive local volume and surface mass-to-light ratios for the Galactic disc, in the bands B, V(More)
  • B Nordström, M Mayor, J Andersen, J Holmberg, F Pont, B R Jørgensen +3 others
  • 2003
We present and discuss new determinations of metallicity, rotation, age, kinematics, and Galactic orbits for a complete, magnitude-limited, and kinematically unbiased sample of 16,682 nearby F and G dwarf stars. Our ∼63,000 new, accurate radial-velocity observations for nearly 13,500 stars allow identification of most of the binary stars in the sample and,(More)