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BACKGROUND Phthalates may pose a risk for perinatal developmental effects. An important question relates to the choice of suitable biological matrices for assessing exposure during this period. OBJECTIVES This study was designed to measure the concentrations of phthalate diesters or their metabolites in breast milk, blood or serum, and urine and to(More)
Research in biomedical text mining is starting to produce technology which can make information in biomedical literature more accessible for bio-scientists. One of the current challenges is to integrate and refine this technology to support real-life scientific tasks in biomedicine, and to evaluate its usefulness in the context of such tasks. We describe(More)
Procedures for risk assessment of chemical mixtures, combined and cumulative exposures are under development, but the scientific database needs considerable expansion. In particular, there is a lack of knowledge on how to monitor effects of complex exposures, and there are few reviews on biomonitoring complex exposures. In this review we summarize articles(More)
BACKGROUND Many practical tasks in biomedicine require accessing specific types of information in scientific literature; e.g. information about the results or conclusions of the study in question. Several schemes have been developed to characterize such information in scientific journal articles. For example, a simple section-based scheme assigns individual(More)
Exocrine pancreatic cancer is an aggressive disease with an exceptionally high mortality rate. Genetic analysis suggests a causative role for environmental factors, but consistent epidemiological support is scarce and no biomarkers for monitoring the effects of chemical pancreatic carcinogens are available. With the objective to identify common traits for(More)
Motivation: Cancer Risk Assessment (RA) of chemicals is an important and challenging multi-step task which requires combining scientific expertise with elaborate literature search and review. Due to the rapidly growing volume of RA literature, the increasing complexity of experimental evidence, and the accelerating need for chemical assessment, the task is(More)
Chemical cancer risk assessment is a literature-dependent task which could greatly benefit from text mining support. In this paper we describe CRAB – the first publicly available tool for supporting the risk assessment workflow. CRAB, currently at version 2.0, facilitates the gathering of relevant literature via PubMed queries as well as semantic(More)
Akt kinase controls cell survival, proliferation, and invasive growth and is a critical factor for cancer development. Here we describe a cross-talk between phosphatases that may preserve levels of activated/phosphorylated Akt and confer aggressive growth of cancer cells. In prostatic cancer cells, but not in non-transformed cells or in prostate stem cells,(More)
MOTIVATION The hallmarks of cancer have become highly influential in cancer research. They reduce the complexity of cancer into 10 principles (e.g. resisting cell death and sustaining proliferative signaling) that explain the biological capabilities acquired during the development of human tumors. Since new research depends crucially on existing knowledge,(More)