Johan A R Ostman

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Paroxysmal extreme pain disorder (PEPD), previously known as familial rectal pain (FRP, or OMIM 167400), is an inherited condition characterized by paroxysms of rectal, ocular, or submandibular pain with flushing. A genome-wide linkage search followed by mutational analysis of the candidate gene SCN9A, which encodes hNa(v)1.7, identified eight missense(More)
Persistent tetrodotoxin-resistant (TTX-r) sodium currents up-regulated by intracellular GTP have been invoked as the site of action of peripheral inflammatory mediators that lower pain thresholds, and ascribed to the Na(V)1.9 sodium channel. Here we describe the properties of a global knock-out of Na(V)1.9 produced by replacing exons 4 and 5 in SCN11A with(More)
While great strides have been made in HVACR technologies in recent years, significant improvements in energy efficiency, reliability and product life have been elusive in mid-range applications. In this 50-500 TR range, the most promising potential for significant energy reduction lies in compressor integrated part load efficiency (IPLV) improvements.(More)
In amyloid diseases, it is not evident which protein aggregates induce cell death via specific molecular mechanisms and which cause damage because of their mass accumulation and mechanical properties. We showed that equine lysozyme assembles into soluble amyloid oligomers and protofilaments at pH 2.0 and 4.5, 57 degrees C. They bind thioflavin-T and Congo(More)
We present nonasymptotic upper and lower bounds on the maximum coding rate achievable when transmitting short packets over a Rician memoryless block-fading channel for a given requirement on the packet error probability. We focus on the practically relevant scenario in which there is no a priori channel state information available at the transmitter and at(More)
We have expressed transthyretin (TTR) mutants which have significantly destabilised tetramers that aggregate into amyloid fibrils via a series of intermediates. We used atomic force microscopy to follow the morphology of aggregates during fibril formation. Initially, amorphous aggregates are formed that subsequently mature into fibrillar structures. This(More)
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