Joeseph A. Church

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Propofol can be used to provide general anesthesia or sedation. Twenty patients scheduled for upper gastrointestinal endoscopy were sedated using a computer-controlled system and endoscopy was performed by the same operator. Oxygen saturation reduced significantly (p less than 0.001) during the procedure, and remained significantly lower than baseline(More)
Forty patients who had undergone coronary artery graft surgery and who required vasodilator therapy for postoperative hypertension were given infusions of either alfentanil or morphine together with bolus doses of midazolam for sedation and analgesia while ventilation was controlled artificially. Sodium nitroprusside (SNP) was administered to both groups(More)
Forty-eight patients were randomised to receive sedation of outpatient dental surgery with midazolam. Sedation was given using the Verrill technique (24 patients) and the Glasgow Dental Hospital technique (24 patients). The differences in recovery and patient acceptability were assessed. There was no statistical difference in mean recovery times between the(More)
Mutations in Sp110 are the underlying cause of veno-occlusive disease with immunodeficiency (VODI), a combined immunodeficiency that is difficult to treat and often fatal. Because early treatment is critically important for patients with VODI, broadly usable diagnostic tools are needed to detect Sp110 protein deficiency. Several factors make establishing(More)
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