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Systematic barriers seem to slow down the market penetration of innovative acethylcholinesterase (AChE) inhibitors in Alzheimer's disease. The goal of our study was to examine the diffusion of AChE inhibitors into the German market in more detail. On the basis of using the ongoing surveillance panel of the Institute of Medical Statistic (IMS) Health, the(More)
OBJECTIVE To investigate the level of detail required in self-reported health care utilization questionnaires for administration to patients with rheumatoid arthritis (RA). METHODS A preliminary questionnaire was developed on the basis of existing tools for use in rheumatic conditions and in-depth interviews with 10 RA patients. Data gathered over 1 year(More)
OBJECTIVE To investigate 1) the magnitude of indirect costs, 2) changes in cost components, and 3) correlations between changes in cost and social, clinical, and occupational variables within the first 3 years of rheumatoid arthritis (RA). METHODS We evaluated the indirect costs per person-year in 133 consecutive gainfully employed out-patients with early(More)
OBJECTIVE To develop a systematic set of German cost data in rheumatoid arthritis (RA) based solely on valid healthcare payer's cost data sources. METHODS Retrospectively one year cost data of 338 patients with RA were generated and analysed. The cost data were derived from a major statutory health insurance plan ("Allgemeine Ortskrankenkasse(More)
OBJECTIVE Transcultural adaptation of the two most widely used and accepted functional indices in ankylosing spondylitis, the Bath Ankylosing Spondylitis Functional Index (BASFI) and Dougados Functional Index (D-FI). METHODS The instruments were translated and tested for internal consistency (Cronbach's coefficient alpha), test-retest reliability(More)
Das Ziel der vorliegenden Arbeit war die transkulturelle Adaptation des „Bath Ankylosing Spondylitis Functional Index“ (BASFI) und des „Dougados Funktionsindex“ (D-FI). Nach der Übersetzung und Rückübersetzung erfolgte die Testung der Verteilungsmuster der Fragebögen, der internen Konsistenz (Cronbach‘s Koeffizient alpha), der Test-Retestzuverlässigkeit(More)
OBJECTIVE To estimate the economic value of pharmacological treatment of type 2 diabetes mellitus in overweight and obese patients using orlistat in addition to standard diabetes therapy (i.e., a sulphonlyurea, metformin or insulin) and weight management strategies as compared with standard diabetes therapy and weight management strategies alone in a(More)
OBJECTIVE To compare the responsiveness of the Bath Ankylosing Spondylitis Functional Index (BASFI), the Dougados Functional Index (DFI), and the ankylosing spondylitis-specific version of the Health Assessment Questionnaire (HAQ-S). METHODS Using data from a placebo controlled, randomized clinical trial we designed a responsiveness model including both(More)
OBJECTIVE To determine rheumatoid arthritis related out of pocket expenditure (OOPE) in Germany and to disaggregate the total OOPE into contributing cost domains. METHODS Data for the cost analysis were drawn from a multicentre randomised controlled prospective trial to assess the effectiveness of clinical quality management in patients with rheumatoid(More)
The objective of this study is to review the concept of the ‘Hannover Costing Study’ and to present and discuss the major insights generated during the course of the project. The costing study was performed in conjunction with a randomized controlled prospective trial assessing the effectiveness of a disease management module in rheumatoid arthritis (RA). A(More)