Joerg Osterhage

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Eye muscles and the sphincter muscles of the bowel and bladder were formerly thought to be spared in amyotrophic lateral sclerosis (ALS), a neurodegenerative disorder. As frequent subclinical impairment of the anal sphincter muscles in ALS has recently been reported, We suspected an earlier and more frequent, if subclinical, involvement of the oculomotor(More)
OBJECTIVE The aim of the present study was to evaluate the therapeutic potency of an electrotherapy of striated ischiocavernous muscles in patients with erectile dysfunction. PATIENTS AND METHODS Transcutaneous electrostimulation of striated ischiocavernous muscles by self-adhesive penile or perineal skin electrodes was performed in 48 patients with(More)
Other outcomes assessed up to week 24 (last MRI scan) • Change in T2 lesion volume from baseline • Proportion of patients free from new T2 lesions • Gd+ lesion count • Proportion of patients free from Gd+ lesions • Proportion of patients free from relapses Analysis sets • Modified full analysis set (mFAS): patients completing 8 weeks of fingolimod therapy(More)
Increasing evidence has suggested that oxidative stress may be involved in the pathogenesis of amyotrophic lateral sclerosis (ALS). The antioxidant vitamin E (alpha-tocopherol) has been shown to slow down the onset and progression of the paralysis in transgenic mice expressing a mutation in the superoxide dismutase gene found in certain forms of familial(More)
BACKGROUND Amyotrophic lateral sclerosis (ALS), a neurodegenerative disorder of unknown origin, was thought to spare the extraocular muscles. Extraocular involvement has recently been reported to occur in the late stages of ALS following respiratory insufficiency. CASE REPORT We report on two patients with ALS who were referred for screening of oculomotor(More)
Neurophysiologic examinations in differential diagnosis of erectile dysfunction comprise electromyogramme of the pelvic floor, pudendal nerve terminal motor latency (PNTML) and evaluation of pudendal somatosensory evoked potentials (SSEP). We focused our interest on comparing diagnostic importance of penile and perianal pudendal nerve SSEP. We examined 20(More)
Penile sympathic skin response (PSSR) was measured in 20 normal patients and in 46 patients with erectile dysfunction (ED). PSSR could be registered in 80% of normal patients. The latencies were 1,100-1,600 ms. In patients with ED, latencies were 1,240-3,640 ms. A reproducible normal latency of PSSR (< 1,600 ms) indicates a normal sympathic innervation of(More)
So far, electrophysiological examinations have rarely been used in the diagnosis of erectile dysfunction (ED) mainly because the methods available only allow somatic neuron pathways to be examined whose relevance for the mainly autonomically controlled crection is evaluated differently. At present, impaired penile nerve supply as the possible cause of ED(More)
Neben einer umfangreichen Anamneseerhebung und klinischen Untersuchung ist eine neurophysiologische Diagnostik auch bei proktologisch-urologischen Fragestellungen sinnvoll. Neurophysiologische Untersuchungsmethoden wie Bulbokavernosus- und Analreflexmessung, Beckenboden-EMG, PNTML (pudendal nerve terminal motor latency) und motorisch evozierte Potentiale(More)
Zu den elektrophysiologischen Untersuchungen in der Diagnostik anorektaler Funktionsstörungen gehört neben dem Beckenboden-EMG und der PNTML (pudendal nerve terminal motor latency) auch die Bestimmung der kortikalen Latenz der P 40 (somatosensibel evozierte Potentiale [SSEP]) des Nervus pudendus. In der Regel erfolgt dies durch penile Stimulation, die(More)