Learn More
Implantable neural microelectrodes that can record extracellular biopotentials from small, targeted groups of neurons are critical for neuroscience research and emerging clinical applications including brain-controlled prosthetic devices. The crucial material-dependent problem is developing microelectrodes that record neural activity from the same neurons(More)
Nanoscale building blocks are individually exceptionally strong because they are close to ideal, defect-free materials. It is, however, difficult to retain the ideal properties in macroscale composites. Bottom-up assembly of a clay/polymer nanocomposite allowed for the preparation of a homogeneous, optically transparent material with planar orientation of(More)
We report the design of surfaces that exhibit dynamic changes in interfacial properties, such as wettability, in response to an electrical potential. The change in wetting behavior was caused by surface-confined, single-layered molecules undergoing conformational transitions between a hydrophilic and a moderately hydrophobic state. Reversible conformational(More)
  • W.-L Huang, Z Ren, Y.-W Lin, H.-Y Chen, J Lahann, T.-C Nguyen +7 others
  • 2008
A fully monolithic oscillator achieved via MEMS-last integration of low temperature nickel micromechanical reso-nator arrays over finished foundry CMOS circuitry has been demonstrated with a measured phase noise of-95 dBc/Hz at a 10-kHz offset from its 10.92-MHz carrier (i.e., output) frequency. The use of a side-supported flexural-mode disk resonator-array(More)
Soft materials that can undergo mechanical actuation in response to external stimuli, [1–7] such as changes in temperature , light, pH value, or ionic strength, have attracted increasing attention because of their potential use as thin-film actuators, [8–10] smart sutures, [11, 12] and soft robots. These materials typically require specialty polymers, such(More)
GOAL We extend a classic signal processing algorithm, the lock-in amplifier, to two dimensions to extract the signal in patterned images. METHODS The algorithm was evaluated using simulated image data and experimental microscopy images to determine the fluorescence signal of fluorescently labeled proteins adsorbed on surfaces patterned with chemical vapor(More)
Stem cells have the ability to self-renew and differentiate into specialized cell types, and, in the human body, they reside in specialized microenvironments called “stem cell niches.” Although several niches have been described and studied in vivo, their functional replication in vitro is still incomplete. The in vitro culture of pluripotent stem cells may(More)
Anisotropic micro-/nanoparticles have been of particular interest due to their potential applications as smart drug carriers , self-assembled hierarchical structures, and biomimetic colloidal building blocks. [ 1–6 ] In the last decade, several sci-entifi c advances led to the preparation of a diverse range of anisotropic particles including particles with(More)
  • 1