Joep Beskers

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Meningococcal outer membrane vesicles (OMVs) have been extensively investigated and successfully implemented as vaccines. They contain pathogen-associated molecular patterns, including lipopolysaccharide (LPS), capable of triggering innate immunity. However, Neisseria meningitidis contains an extremely potent hexa-acylated LPS, leading to adverse effects(More)
Outer membrane vesicles (OMVs) are spherical nanoparticles that naturally shed from Gram-negative bacteria. They are rich in immunostimulatory proteins and lipopolysaccharide but do not replicate, which increases their safety profile and renders them attractive vaccine vectors. By packaging foreign polypeptides in OMVs, specific immune responses can be(More)
DECORATION OF OUTER MEMBRANE VESICLES WITH MULTIPLE 1 ANTIGENS USING AN AUTOTRANSPORTER APPROACH 2 3 Maria H Daleke-Schermerhorn, Tristan Felix, Zora Soprova, Corinne M ten Hagen4 Jongman, David Vikström, Laleh Majlessi, Joep Beskers, Frank Follmann, Karin 5 de Punder, Nicole N van der Wel, Thomas Baumgarten, Thang V Pham, Sander R 6 Piersma, Connie R(More)
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