Joelle Chalmer

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Cytotoxic activity attributable to natural killer (NK) cells was augmented in the spleens of mice infected with murine cytomegalovirus (MCMV). Stimulation was observed as early as 10 hr after virus administration but was dependent upon the dose used, and in particular, the host genotype. Effector cells were capable of killing a range of tumor cell targets(More)
C57BL and BALB/c mice were exposed to fresh cigarette smoke for 7-8 minutes per day for varying periods up to 30 weeks before subcutaneous or intratracheal inoculation of viable tumor cells. The growth rates of subcutaneous tumors in the mice exposed to smoke were significantly higher than those of controls and more lung metastases were noted. Enhanced(More)
Studies of the resistance patterns to infection with a murine cytomegalovirus in inbred strains of mice revealed the existence of resistant and susceptible strains. Resistance was found to be associated with possession of the H-2k allele at the major histocompatibility locus of the mouse. The F1 hybrid between a resistant strain (C3H/HeJ) and a susceptible(More)
Tumor-specific, cell-mediated immune responses (CMI) in mice were measured during the growth of transplantable tumors with the use of lymphocyte-mediated cytotoxicity and the recently developed leukocyte adherence inhibition (LAI) microtest. When both tests were used in parallel to assess CMI, no consistent correlation was found, which suggested that each(More)
Mice were exposed for 7 to 8 minutes on weekdays to fresh smoke from high-tar (HT) or low-tar (LT) cigarettes for varying periods of up to 36 weeks. Mice exposed to HT cigarettes exhibited more marked alterations in humoral immune responsiveness, hematological profiles, and pulmonary pathologic findings than those exposed to LT cigarettes. However,(More)
BACKGROUND Immobilisation and early motion (protected or unrestricted) are both used following hyperextension injuries to the proximal interphalangeal (PIP) joint of the finger. OBJECTIVES To assess the effects of conservative interventions (non-surgical management) for treating hyperextension injuries of the proximal interphalangeal joints of the(More)
There is no consensus on the most effective rehabilitation regimen following extensor tendon repair of the hand. This systematic review evaluates the outcomes of the various regimens. The Cochrane, MEDLINE, EMBASE, CINAHL, AMED, PEDro, OTseeker databases were searched for any prospective randomised clinical trials comparing rehabilitation regimens for acute(More)
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