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For the last two decades, the involvement of 5-HT(1A) receptors in the regulation of vigilance states has been studied extensively thanks to pharmacological tools, but clear-cut conclusion has not been reached yet. By studying mutant mice that do not express this receptor type (5-HT(1A)-/-) and their wild-type 129/Sv counterparts, we herein demonstrate that(More)
Recent evidence indicates that pituitary adenylate cyclase-activating polypeptide (PACAP) and vasoactive intestinal polypeptide (VIP) might play an important role in rapid eye movement sleep (REMS) generation at the pontine level in rats. We have thus examined the immunohistochemical distribution of VIP and PACAP in the pontine and mesencephalic areas known(More)
OBJECTIVES To evaluate and compare the effects of melatonin and levodopa (L-dopa) on sleep disorders in a monkey model of Parkinson's disease. MATERIALS AND METHODS The daytime and nighttime sleep patterns of four macaques that were rendered parkinsonian by administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) were recorded using(More)
One picogram of synthetic arginine vasotocin (AVT) administered into the lateral ventricle of newborn cats aged 7-9 days, increased the amount of quiet sleep and markedly decreased the amount of active sleep. Ten pg AVT completely suppressed active sleep during the recording time of 3 hr. The increase in the quiet sleep occurred within 5-7 min and lasted(More)
I earned my Ph.D. in physiology and physiopathology in 2008 at the University Pierre & Marie Curie (UPMC) in Paris. My research interests were initially oriented on the brainstem neural circuits governing sleep/wake transitions with a particular focus on the serotonin (5-HT) signaling. As I joined Luis de Lecea's lab as a postdoc fellow, I pursued studying(More)
Bilateral electrocoagulation of the locus coeruleus (LC) were performed in 8 cats, in order to study the effects on the heart rate modulation during sleep. In 4 cats the lesions were restricted to the posterior part of LC: they induced a permanent tachycardia in all states, and a reduction of the phasic changes during paradoxical sleep (PS), while the(More)
Electrolytic lesions were used to destroy the anterior raphe nuclei and the loci caeruleus and subcaeruleus in kittens at varying stages of maturation. No lesion performed in the first week after birth led to changes in the characteristics of sleep in the 8 post-operative days. On the other hand, lesions performed in kittens aged 1-2 months had the same(More)
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