Joel P. Giblett

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ATP-binding-cassette-transporter-A1 (ABCA1) plays a pivotal role in intracellular cholesterol removal, exerting a protective effect against atherosclerosis. ABCA1 gene severe mutations underlie Tangier disease, a rare Mendelian disorder that can lead to premature coronary artery disease (CAD), with age of CAD onset being two decades earlier in mutant(More)
Ischaemia-reperfusion (IR) injury is an important cause of myocardial damage during percutaneous coronary intervention (PCI). There are few therapies in widespread clinical use which impact on IR injury and it remains an important and underutilized target for treatment in acute myocardial infarction. This review will examine the translational scientific(More)
This review examines the rationale for using remote ischemic conditioning (RIC) in elective percutaneous coronary intervention (PCI) to prevent procedure-related ischemia-reperfusion injury and justifies the importance of periprocedural biomarker elevation following elective PCI as a valid target for RIC. We review the evidence for the use of RIC as a(More)
AIMS Randomised trials have shown that direct stenting (DS) is associated with improved markers of reperfusion during primary percutaneous coronary intervention (PPCI) for ST elevation myocardial infarction (STEMI). However, data evaluating its impact on long-term clinical outcomes are lacking. We set out to evaluate the effect of DS on mortality in a(More)
BACKGROUND Glucagon-like peptide-1 (7-36) amide (GLP-1) protects against stunning and cumulative left ventricular dysfunction in humans. The mechanism remains uncertain but GLP-1 may act by opening mitochondrial K-ATP channels in a similar fashion to ischemic conditioning. We investigated whether blockade of K-ATP channels with glibenclamide abrogated the(More)
BACKGROUND We sought to determine whether right ventricular stunning could be detected after supply (during coronary balloon occlusion [BO]) and supply/demand ischemia (induced by rapid pacing [RP] during transcatheter aortic valve replacement) in humans. METHODS AND RESULTS Ten subjects with single-vessel right coronary artery disease undergoing(More)
TCT-403 Bioresorbable Coronary Devices in Bifurcations: Immediate and 6-month Results of the REPARA Registry Felipe Hernandez, Jose M. de la Torre Hernandez, Bruno Garcia, Jose Rumoroso, Ramiro Trillo, Armando Perez de Prado, eduardo molina, Raul Moreno, Jose Diaz, Ivan Gomez Blazquez, Hipolito Gutierrez, Pedro Canas da Silva, Vasco Gama Ribeiro Hospital 12(More)
(A) RV Tau at baseline (pre-TAVR), after rapid pacing to test capture (RPT baseline right ventricular (RV) function. Values are mean SEM. Compar **p < 0.01; ***p < 0.001. TAVR 1⁄4 transcatheter aortic valve replaceme on right ventricular (RV) function is less well described. Pre-TAVR RV dysfunction independently predicts outcome post-TAVR (2), and(More)
Unknown; Seoul National University Hospital, Seoul, Korea, Republic of; Seoul National University Hospital, Seoul, Korea, Republic of; Brest University, Brest, France; Institut Cardiovasculaire Paris Sud, Massy, France; Emory, Atlanta, Georgia, United States; Policlinico Umberto I University, Rome, Italy; Saint Luke’s Mid America Heart Institute; Columbia(More)