Joel M Manaligod

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Recent studies indicate that maximal IL-8 protein expression requires activation of NF-kappaB as well as activation of the MAP kinases ERK, JNK, and p38. However, the precise relationship between NF-kappaB transactivation and MAP kinase activation remains unclear. We examined the requirements of NF-kappaB, ERK, JNK, and p38 for TNF-alpha-induced(More)
The purpose of this study was to evaluate the pharmacokinetic profile of intranasal lorazepam in comparison to currently established administration routes. Eleven healthy volunteers completed this randomized crossover study. On three occasions, each separated by a 1-week washout, subjects received a 2 mg dose of lorazepam via the intranasal, intravenous, or(More)
This study was undertaken to examine the degree of renal (R) functional and structural (S) involvement in STZ-Insulin (I) dependent (STZI, for 3-8 years; I requirement 2-7 U/day) or STZ carbohydrate disturbed (CHO, for 3-9 years) or Px (for 2-4 years; I, 2-7 U/day) model of diabetes (D) in RM. Glomerular filtration rate (GFR) renal plasma flow (RPF) urinary(More)
STUDY OBJECTIVES To determine the effects of different levels of positive end-expiratory pressure (PEEP) during partial liquid ventilation (PLV) on gas exchange, lung compliance, and end-expiratory lung volume (EELV). DESIGN Prospective animal study. SETTING Animal physiology research laboratory. SUBJECTS Nine piglets. INTERVENTIONS Animals(More)
In an 11-year study of experimental insulin-deficient diabetes (IDDM) induced in rhesus monkeys by streptozotocin or total pancreatectomy, the authors have found that pathophysiologic changes occur in eye and kidney, which closely resemble the early stages of human insulin deficient diabetes mellitus (IDDM). In addition, morphologic changes of thickening of(More)
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