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Polymerization of actin filaments directed by the actin-related protein (Arp)2/3 complex supports many types of cellular movements. However, questions remain regarding the relative contributions of Arp2/3 complex versus other mechanisms of actin filament nucleation to processes such as path finding by neuronal growth cones; this is because of the lack of(More)
Nitric oxide (NO) is an important messenger both systemically and in the CNS. In digital Ca2+ imaging and patch-clamp experiments, clinically available nitroso compounds that generate NO are shown to inhibit responses mediated by the NMDA subtype of the glutamate receptor on rat cortical neurons in vitro. A mechanism of action for this effect was(More)
The authors describe relationships among infrastructure, student outcomes, and faculty satisfaction at the University of Central Florida (UCF). The model focuses on a developmental process that progresses from courses with some Web presence to those that are driven by ALN. Faculty receive support for on-line teaching in the form of release time for training(More)
The Kepler spacecraft is monitoring more than 150,000 stars for evidence of planets transiting those stars. We report the detection of two Saturn-size planets that transit the same Sun-like star, based on 7 months of Kepler observations. Their 19.2- and 38.9-day periods are presently increasing and decreasing at respective average rates of 4 and 39 minutes(More)
The authors explore blended learning environments from metaphorical and generational perspectives. They suggest that the language of higher education reflects metaphors that evolve for the academy, faculty, and students. Generational markers for Mature, Baby­Boomer, Generation X, and Millennial student cohorts interact with blended learning satisfaction.(More)
Citation Albrecht, Simon et al. " Obliquities of hot Jupiter host stars: Evidence for tidal interactions and primordial misalignments. The MIT Faculty has made this article openly available. Please share how this access benefits you. Your story matters. ABSTRACT We provide evidence that the obliquities of stars with close-in giant planets were initially(More)
The Kepler mission is monitoring the brightness of ~150,000 stars, searching for evidence of planetary transits. As part of the Hunt for Exomoons with Kepler (HEK) project, we report a planetary system with two confirmed planets and one candidate planet discovered with the publicly available data for KOI-872. Planet b transits the host star with a period(More)
Aims. Study the high-mass X-ray binary X-7 in M33 using broad-band optical data. Methods. We used recently published CFHT r ′ and i ′ data for variable stars in M33 to extract the light curve of the optical counterpart of X-7. We combined these data with DIRECT B and V measurements in order to search for an independent optical modulation with the X-ray(More)
Stellar-mass black holes are found in X-ray-emitting binary systems, where their mass can be determined from the dynamics of their companion stars. Models of stellar evolution have difficulty producing black holes in close binaries with masses more than ten times that of the Sun (>10; ref. 4), which is consistent with the fact that the most massive stellar(More)
Increasing evidence suggests heterogeneity in the molecular pathogenesis of cystic fibrosis (CF). Mutations such as deletion of phenylalanine at position 508 (delta F508) within the cystic fibrosis transmembrane conductance regulator (CFTR), for example, appear to cause disease by abrogating normal biosynthetic processing, a mechanism which results in(More)