Joel Alvim

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A doença de Chagas, causada pelo Trypanosoma cruzi, é endêmica em 15 países na América Latina. Neste trabalho uma coleção de 38 cumarinas foi preparada em solução e testada frente à enzima gliceraldeído-3-fostafo-desidrogenase (gGAPDH) do T. cruzi. A rota sintética foi baseada na condensação de Knoevenagel de diferentes 2-hidroxibenzaldeídos com ácido de(More)
Cathepsin V is a papain-like cysteine protease. It is involved in the control of human T cells (responsible for cell immunity), and presents the largest elastolytic activity among the proteolytic enzymes. Therefore, cathepsin V is a potential molecular target for the treatment of atherosclerosis. In the present work, natural flavonoids were screened against(More)
To study the structure-activity relationship of coumarin (-) mammea A/BB isolated from the CH(2)Cl(2) extract of Calophyllum brasiliense leaves, we evaluated the antileishmanial activity of natural, synthetic and derivatives of this coumarin, against promastigote and intracellular amastigote forms of Leishmania amazonensis, and their cytotoxicity to J774G8(More)
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