Joel A. Block

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Increased knee joint loads during walking are present in subjects with knee osteoarthritis.

Algis J Baliunas, Debra E. Hurwitz, +4 authors Thomas P. Andriacchi
Osteoarthritis and cartilage
2002

OBJECTIVE This study tests the hypothesis that the peak external knee adduction moment during gait is increased in a group of ambulatory subjects with knee osteoarthritis (OA) of varying radiographic… (More)

The knee adduction moment during gait in subjects with knee osteoarthritis is more closely correlated with static alignment than radiographic disease severity, toe out angle and pain.

Debra E. Hurwitz, A B Ryals, John P. Case, Joel A. Block, Thomas P. Andriacchi
Journal of orthopaedic research : official…
2002

This study tested whether the peak external knee adduction moments during walking in subjects with knee osteoarthritis (OA) were correlated with the mechanical axis of the leg, radiographic measures… (More)

Knee pain and joint loading in subjects with osteoarthritis of the knee.

Debra E. Hurwitz, A R Ryals, Joel A. Block, L. Amarnath Sharma, Thomas J. Schnitzer, Thomas P. Andriacchi
Journal of orthopaedic research : official…
2000

Although treatments for osteoarthritis of the knee are often directed at relieving pain, pain may cause patients to alter how they perform activities to decrease the loads on the joints. The… (More)

A novel proteoglycan synthesized and secreted by chondrocytes of the superficial zone of articular cartilage.

Barbara L. Schumacher, Joel A. Block, Thomas M. Schmid, Margaret B. Aydelotte, Klaus E. Kuettner
Archives of biochemistry and biophysics
1994

A novel proteoglycan (PG) has been identified in culture medium from thin slices of the superficial zone of bovine articular cartilage. This PG is synthesized and secreted selectively by chondrocytes… (More)

Knee joint loading differs in individuals with mild compared with moderate medial knee osteoarthritis.

Laura E. Thorp, Dale Richman Sumner, Joel A. Block, Kirsten C. Moisio, Susan B Shott, Markus A Wimmer
Arthritis and rheumatism
2006

OBJECTIVE To compare the knee joint loading patterns in individuals with differing radiographic grades of knee osteoarthritis (OA) for characterization of the mechanical implications of different… (More)

Nonrandom evolution of end-stage osteoarthritis of the lower limbs.

Najia Shakoor, Joel A. Block, Susan B Shott, John P. Case
Arthritis and rheumatism
2002

OBJECTIVE Patients with unilateral hip or knee replacements for end-stage osteoarthritis (OA) are at high risk for future progression of OA in other joints of the lower extremities, often requiring… (More)

Basic fibroblast growth factor stimulates matrix metalloproteinase-13 via the molecular cross-talk between the mitogen-activated protein kinases and protein kinase Cdelta pathways in human adult…

Hee-Jeong Im, Prasuna Muddasani, +5 authors Richard F. Loeser
The Journal of biological chemistry
2007

Excessive release of basic fibroblast growth factor (bFGF) during loading and/or injury of the cartilage matrix may contribute to the onset or progression of osteoarthritis. This pathological role… (More)

A thin-layer model for viscoelastic, stress-relaxation testing of cells using atomic force microscopy: do cell properties reflect metastatic potential?

Eric M Darling, Stefan Zauscher, Joel A. Block, Farshid Guilak
Biophysical journal
2007

Atomic force microscopy has rapidly become a valuable tool for quantifying the biophysical properties of single cells. The interpretation of atomic force microscopy-based indentation tests, however,… (More)

Asymmetric knee loading in advanced unilateral hip osteoarthritis.

Najia Shakoor, Debra E. Hurwitz, Joel A. Block, Susan B Shott, John P. Case
Arthritis and rheumatism
2003

OBJECTIVE Subjects with unilateral end-stage hip osteoarthritis (OA) who undergo total hip replacement (THR) preferentially require subsequent replacement of the contralateral knee compared with the… (More)

Reduced lower extremity vibratory perception in osteoarthritis of the knee.

Najia Shakoor, Alan Agrawal, Joel A. Block
Arthritis and rheumatism
2008

OBJECTIVE Vibratory perception threshold (VPT) assesses a distinct yet related sensory pathway that has been associated with neuropathic arthropathy but has not been assessed in knee osteoarthritis… (More)

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