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The function of the majority of genes in the mouse and human genomes remains unknown. The mouse embryonic stem cell knockout resource provides a basis for the characterization of relationships between genes and phenotypes. The EUMODIC consortium developed and validated robust methodologies for the broad-based phenotyping of knockouts through a pipeline(More)
The broad aim of biomedical science in the postgenomic era is to link genomic and phenotype information to allow deeper understanding of the processes leading from genomic changes to altered phenotype and disease. The EuroPhenome project (http://www.EuroPhenome.org) is a comprehensive resource for raw and annotated high-throughput phenotyping data arising(More)
  • Soroush Vosoughi, Allen Gorin, Brandon Roy, Jeff Orkin, Philip Decamp, Karina Lundahl +37 others
  • 2015
The spread of malicious or accidental misinformation in social media, especially in time-sensitive situations such as real-world emergencies can have harmful effects on individuals and society. This thesis develops models for automated detection and verification of rumors (unverified information) that propagate through Twitter. Detection of rumors about an(More)
Understanding the functions encoded in the mouse genome will be central to an understanding of the genetic basis of human disease. To achieve this it will be essential to be able to characterise the phenotypic consequences of variation and alterations in individual genes. Data on the phenotypes of mouse strains are currently held in a number of different(More)
Two bottlenecks impeding the genetic analysis of complex traits in rodents are access to mapping populations able to deliver gene-level mapping resolution and the need for population-specific genotyping arrays and haplotype reference panels. Here we combine low-coverage (0.15×) sequencing with a new method to impute the ancestral haplotype space in 1,887(More)
  • Mark Lehne, Sanjay Raman, Jeffrey H Reed, Steven W Ellingson, Joseph G Tront, Cameron Patterson +11 others
  • 2008
As Orthogonal Frequency Division Multiplexing (OFDM) becomes more prevalent in new leading-edge data rate systems processing spectral bandwidths beyond 1 GHz, the required operating speed of the baseband signal processing, specifically the Analog-to-Digital Converter (ADC) and Fast Fourier Transform (FFT) processor, presents significant circuit design(More)
OBJECTIVE Determine whether United States Air Force (USAF) U-2 pilots (U2Ps) with occupational exposure to repeated hypobaria had lower neurocognitive performance compared to pilots without repeated hypobaric exposure and whether U2P neurocognitive performance correlated with white matter hyperintensity (WMH) burden. METHODS We collected Multidimensional(More)
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