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BACKGROUND Epilepsy is a common neurological disorder that affects approximately 50 million people worldwide. Both risk of epilepsy and response to treatment partly depend on genetic factors, and gene identification is a promising approach to target new prediction, treatment, and prevention strategies. However, despite significant progress in the(More)
This article proposes an analytical framework to better understand the role that information and communication technology (ICT) skills play in improving employment opportunities for low-income groups. The paper draws upon research with over seventy non-governmental organizations (NGOs) that provide ICT training and other employment services in 30 countries(More)
This paper describes the application of evolutionary search to the problem of Flash memory wear-out. The current method for establishing memory operating parameters is a time consuming and expensive manual process of destructive testing. Understandably this process is normally undertaken only at design time. The results are sub optimum solutions which do(More)
Infantile spasms (IS) and Lennox-Gastaut syndrome (LGS) are epileptic encephalopathies characterized by early onset, intractable seizures, and poor developmental outcomes. De novo sequence mutations and copy number variants (CNVs) are causative in a subset of cases. We used exome sequence data in 349 trios with IS or LGS to identify putative de novo CNVs.(More)
Extensive social psychological research emphasises the importance of groups in shaping individuals' thoughts and actions. Within the child sexual abuse (CSA) literature criminal organisation has been largely overlooked, with some key exceptions. This research was a novel collaboration between academia and the UK's Child Exploitation and Online Protection(More)