Joe C Kidney

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Theophylline is the most widely used anti-asthma drug worldwide and is classified as a bronchodilator, although there is increasing evidence that it may have immunomodulatory effects. We have investigated the effects of theophylline withdrawal under placebo control in 27 asthmatic patients (25 to 70 yr) treated with long-term theophylline who were also(More)
BACKGROUND Potassium (K+) channel activators, such as cromakalim, open ATP sensitive K+ channels and relax airway smooth muscle in vitro and inhibit induced bronchoconstriction in vivo in animals. The prolonged half life of cromakalim gives it potential as an oral bronchodilator. The effect of orally administered BRL 38227 (the active enantiomer of(More)
We determined whether platelet-activating factor (PAF) caused bronchoconstriction through the release of leukotrienes (LT) by studying the effect of a potent LTD4 receptor antagonist, ICI 204,219, on PAF-induced bronchoconstriction in normal subjects. Eight males (age 20 to 36 yr) were given either 40 mg ICI 204,219 orally or matching placebo on 2 study(More)
Since orally administered K+ channel openers may have cardiovascular side effects, it is possible that inhaled administration would be preferred for the treatment of asthma. We have investigated whether inhaled levcromakalim and HOE 234 inhibit histamine-induced bronchoconstriction and airway plasma exudation in anaesthetised guinea pigs. We have also(More)
Editor, We report on a 64 year old gentleman who developed an early broncho-pleural fistula following a double lung transplant for end-stage COPD/Bronchiectasis and was transferred to his referring institution for palliative management. Ten weeks post-transplant, the patient developed sudden-onset severe epigastric/right upper quadrant abdominal pain. He(More)
Paget-Schroetter syndrome is thrombosis of the subclavian or axillary vein due to repetitive use of the upper limbs. We present a case of Paget-Schroetter syndrome in a man who regularly performed weightlifting as part of his routine workout at the gymnasium. The mechanisms of the disease and its treatment are discussed. This diagnosis should be considered(More)
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