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Processing of DNA for nonhomologous end-joining by cell-free extract.

• Joe Budman, Gilbert Chu
• The EMBO journal
• 2005

In mammalian cells, nonhomologous end-joining (NHEJ) repairs DNA double-strand breaks created by ionizing radiation and V(D)J recombination. We have developed a cell-free system capable of processing… (More)

Processing of DNA for nonhomologous end-joining is controlled by kinase activity and XRCC4/ligase IV.

• Joe Budman, Sunny Kim, Gilbert Chu
• The Journal of biological chemistry
• 2007

Nonhomologous end-joining (NHEJ) repairs DNA double-strand breaks created by ionizing radiation and V(D)J recombination. To repair the broken ends, NHEJ processes noncompatible ends into a ligatable… (More)

Concomitant angiotensin AT1 receptor antagonism and neprilysin inhibition produces omapatrilat-like antihypertensive effects without promoting tracheal plasma extravasation in the rat.

• Laxminarayan G Hegde, Cecile Yu, +11 authors Sharath S. Hegde
• Journal of cardiovascular pharmacology
• 2011

Dual inhibition of angiotensin-converting enzyme (ACE) and neprilysin (NEP) by drugs such as omapatrilat produces superior antihypertensive efficacy but cause high incidence of angioedema. We… (More)

Assays for nonhomologous end joining in extracts.

• Joe Budman, Gilbert Chu
• Methods in enzymology
• 2006

In mammalian cells, nonhomologous end-joining (NHEJ) repairs DNA double strand breaks created by ionizing radiation and V(D)J recombination. Using human whole cell extracts prepared by the method of… (More)

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