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BACKGROUND Doxorubicin and cyclophosphamide (AC) therapy is an effective treatment for early-stage breast cancer. Doxorubicin is a substrate for ABCB1 and SLC22A16 transporters. Cyclophosphamide is a prodrug that requires oxidation to 4-hydroxycyclophosphamide, which yields a cytotoxic alkylating agent. The initial oxidation is catalysed by cytochrome P450(More)
Second language learners tend to transfer phonological constraints and pronunciations from their first language (L1) into their second language (L2) (Gass and Selinker 1994). Optimality Theory (Prince & Smolensky 1993) captures the phonology of the L1 using a system of ranked constraints. The ranking of constraints provides us with a detailed understanding(More)
Rats immune to one of 6 syngeneic tumours with individually distinct tumour associated rejection antigens, or rats bearing growing tumours were tested for cell mediated immunity to their own or other tumours in comparison with normal control rats using a microcytotoxicity assay. Lymph node cells (LNC) were tested at ratios of 2000, 1000, 500 and 250 per(More)
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