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Journals and Conferences
Insulin, glucagon, and somatostatin secretion were evaluated in the following isolated perfused models: rat pancreas-duodenum (both normal and streptozotocin-diabetic animals) and the chicken pancreas with and without duodenum. Insulin secretion in response to glucose or arginine was greater from the normal rat than either the diabetic rat or the chicken.… (More)
The binding of the potent anticarcinogenic agent, dexamethasone, to mouse epidermal and dermal subcellular fractions was investigated. When applied to mouse skin, 3H-labeled dexamethasone remained associated, after extensive dialysis, with epidermal and dermal cytosol, microsomes, microsomes, mitochondria, and chromatin. The specific activity of… (More)
Monomeric IgM could be found rather frequently in acute hepatitis and chronic aggressive hepatitis and occasionally also in chronic persistent hepatitis. Earlier it was reported in lympho-proliferative-, autoimmune diseases, some infectious diseases and in cirrhosis of the liver. The occurence of monomeric IgM in chronic aggressive hepatitis correlates with… (More)
The secretory organelles of Toxoplasma gondii orchestrate invasion of the host cell and establish the parasitophorous vacuole. Although much has been learned about the roles played by these organelles in invasion by the tachyzoite stage, little is known about the contents or functions of these organelles during bradyzoite development or pathogenesis. We… (More)
Skin allograft rejection was noticeably delayed in rats following hypophysectomy. Daily injections of hypophyseal growth hormone restored the normal reaction. Additional thymectomy had no influence on the rejection of hypophysectomized rats. In these animals growth hormone by itself had no significant influence on the graft rejection. It only restored a… (More)
In a 70-year old woman presenting with extended coumarin-necroses on her right thigh and shin histological findings, immunofluorescence and coagulation-parameters favoured a mechanism closely related to a local Sanarelly-Shwartzman-reaction. A primary immunological process involving the vessel walls could be ruled out.
Starting with a pathological IgM-precipitate in immunoelectrophoresis during the last 4 years, a patient developed Waldenström's disease with several osteolytic lesions. In the terminal stage lymphoid and so called Waldenström's cells occurred in peripheral blood. The isolated macroglobulin behaved as a cryoglobulin with antinuclear activity. Besides… (More)
7S-IgM is the first specific antibody during evolution of vertebrates. The detection of monomeric IgM in monoclonal grammopathies, autoimmune and infectious diseases is believed to be an atavistic primary IgM response in cases of elevated humoral immune reactions and disorders of lymphatic tissues.
The phylogenetic development of the immune system can be closely followed by the evolutionary tree of vertebrates. Primitive fishes were the first to develop one after another lymphocyte aggregations in the intestine, the spleen, the thymus and the first plasma cells. In these animals, tissue grafts were rejected chronically and antibodies of the IgM-class… (More)