Jochen Sieber

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Sublingual immunotherapy has been shown in some clinical studies to modulate allergen-specific antibody responses [with a decrease in the immunoglobulin E/immunoglobulin G4 (IgE/IgG4) ratio] and to reduce the recruitment and activation of proinflammatory cells in target mucosa. Whereas a central paradigm for successful immunotherapy has been to reorient the(More)
OBJECTIVE We assessed medication persistence using prescription renewal rates for grass pollen specific immunotherapy (SIT) in a representative population of patients in Germany to evaluate whether the perception of superior persistence for the subcutaneous route compared to the sublingual route could be confirmed in clinical practice. METHODS Individual(More)
BACKGROUND Data supporting a carry-over effect with sublingual immunotherapy (SLIT) are scarce. This randomized, double-blind, placebo-controlled study evaluated the efficacy, carry-over effect and safety of grass pollen SLIT using co-seasonal treatment. METHODS Patients (7.9-64.7 years) with grass pollen allergy received ultra-rush titration with(More)
Combined symptom and medication score First treatment period (season 1) 0.97 1.28 .0427 Second treatment period (season 2) 20.95 0.06 .0401 Third treatment period (season 3) 21.35 0.56 .0019 Follow-up period 21.76 21.19 .0523 Symptom score First treatment period (season 1) 20.03 1.49 .0366 Second treatment period (season 2) 20.89 0.91 .0235 Third treatment(More)
202 Treatment Satisfaction with Sublingual Immunotherapy in a Real-Life Setting Meike Hadler, Silvia Schnitzer,MD, PhD, Jörg Schnitker, and Jochen Sieber, MD, PhD. Medical Department, Stallergenes GmbH, Kamp-Lintfort, Germany; Private Office, Grevesmuehlen, Germany; Institut für angewandte Statistik, Bielefeld, Germany. Background: By now, the efficacy and(More)
BACKGROUND The impact of treatments for allergic rhinitis on health-related quality of life (HRQL) becomes more and more important in the view of patients, physicians and payers, but not much is known about the effect of sublingual immunotherapy (SLIT) on this outcome parameter. METHODS In a prospective observational study, health-related quality of life(More)
OBJECTIVE We conducted a large observational study in 193 children and adolescents with allergic rhinitis due to grass or tree pollens to evaluate the safety and tolerability of an ultrarush high-dose sublingual immunotherapy (SLIT) regimen reaching a maintenance dose of 300 index of reactivity within 90 minutes. METHODS Children and adolescents aged 5 to(More)
Abstract Background. Despite strong evidence for subcutaneous and sublingual immunotherapy for the treatment of allergic rhinoconjunctivitis, comparative data are scarce. Objectives. We performed an individual patient data meta-analysis of four observational studies to compare the effectiveness of both application routes. Methods. After individual analysis,(More)
BACKGROUND Sublingual immunotherapy (SLIT) is safer than subcutaneous immunotherapy (SCIT) and this has lead to the reconsideration of the use of ultra-rush schedules for SLIT. The aim of this study was to assess the safety of ultra-rush SLIT in pollen-allergic children according to different timing of administration in relation to the pollen season. (More)
BACKGROUND The safety and efficacy of pre- and coseasonal sublingual allergen immunotherapy (SLIT) with a 5-grass pollen sublingual tablet have been demonstrated in a randomized clinical trial (RCT) in children and adolescents. Observational, 'real-life' studies can usefully complement the results of RCTs. METHODS A prospective, open-label, observational,(More)