Jochen Schneider

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When blind people wish to walk through an area not fully known to them, they have to prepare themselves even more thoroughly than sighted pedestrians. We propose a new approach to support this preparation with the help of an interactive computer method, called constructive exploration. Using this method, the user is guided in physically constructing the(More)
MiRNAs are increasingly recognized as biomarkers for the diagnosis of cancers where they are profiled from tumor tissue (intracellular miRNAs) or serum/plasma samples (extracellular miRNAs). To improve detection of reliable biomarkers from blood samples, we first compiled a healthy reference miRNome and established a well-controlled analysis pipeline(More)
BACKGROUND Increased risk of osteoporosis and its clinical significance in patients with diabetes is controversial. We analyze osteoporosis prevalence and determinants of bone mineral density (BMD) in patients with type 1 and 2 diabetes. METHODS Three hundred and ninety-eight consecutive diabetic patients from a single outpatient clinic received a(More)
Bile acids (BAs) are increasingly recognised as metabolic regulators, potentially improving insulin sensitivity following bariatric surgery. However, physiological relevance of such observations remains unknown. Hence, we analysed serum BA composition and associated gut-derived hormone levels following lifestyle-induced weight loss in individuals with(More)
Animal testing plays a vital role in biomedical research. Stress reduction is important for improving research results and increasing the welfare and the quality of life of laboratory animals. To estimate stress we believe it is of great importance to develop non-invasive techniques for monitoring physiological signals during the transport of laboratory(More)
Anti-angiogenic treatments against αvβ3-integrin fail to block tumour growth in the long term, which suggests that the tumour vasculature escapes from angiogenesis inhibition through αvβ3-integrin-independent mechanisms. Here, we show that suppression of β3-integrin in mice leads to the activation of a neuropilin-1 (NRP1)-dependent cell migration pathway in(More)
Serotonin acts as neurotransmitter in the brain and as a multifaceted signaling molecule coordinating many physiological processes in the periphery. In a recent issue of Nature Medicine, Crane et al. (2014) find that peripheral serotonin controls thermogenesis in adipose tissue by modulating β-adrenergic stimulation of UCP-1, thereby affecting glucose(More)
Purpose Interviews were conducted in a large managed care organization (MCO) to explore the integration of community CAM services (acupuncture and chiropractic) with conventional care for chronic pain patients. Methods Primary care providers (PCPs) were recruited, stratified on their rates of patient referral to CAM therapies. Acu-puncturists and(More)