Jochen Salfeld

Learn More
IL-lp-converting enzyme (ICE) cleaves pro-IL-lp to generate mature IL-lp. ICE is homologous to other proteins that have been implicated in apoptosis, including CED-3 and Nedd-2/Ich-1. We generated ICE-deficient mice and observed that they are overtly normal but have a major defect in the production of mature IL-1I~ after stimulation with lipopolysaccharide.(More)
  • 1