Jochen Rossler

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Two monoclonal antibodies, AXO 49 and TAP 952, probed with carboxy-terminal peptides from Paramecium axonemal tubulin and with polyglycylated synthetic peptides, are found to recognize differently tubulin polyglycylation, the most recently identified posttranslational modification discovered in Paramecium axonemal tubulin. With these antibodies, we show(More)
BACKGROUND Ulceration is a frequent complication of proliferating haemangioma. METHODS Four patients with ulcerated hemangioma aged 2, 4, 5 months and 5 weeks were treated with 2 mg/kg KG propranolol. RESULTS Efficacy and safety of propranolol were excellent in all four cases. CONCLUSIONS Propranolol may be the first-choice therapy for ulcerated(More)
D. Spirkoska,1 J. Arbiol,2 A. Gustafsson,3 S. Conesa-Boj,2 F. Glas,4 I. Zardo,1 M. Heigoldt,1 M. H. Gass,5 A. L. Bleloch,5 S. Estrade,2 M. Kaniber,1 J. Rossler,1 F. Peiro,2 J. R. Morante,2,6 G. Abstreiter,1 L. Samuelson,3 and A. Fontcuberta i Morral1,7 1Walter Schottky Institut and Physik Department, Technical University of Munich, Am Coulombwall 3, 85748(More)
BACKGROUND Patients with fibromatosis not amenable to surgery may suffer from high morbidity. Various chemotherapeutic regimens have been tried in these patients with limited success. Here, we report on the successful use of pegylated liposomal doxorubicin in the treatment of 4 patients with unresectable fibromatosis in unfavorable localizations. PATIENTS(More)
This report documents the clinical activity of caspofungin in a 13-year-old girl with acute myeloid leukemia (AML) and chronic disseminated candidiasis (CDC), refractory to amphotericin B and fluconazole. Caspofungin was started at 50 mg/d resulting in a temporary response. With no further clinical improvement and radiological progress after 2 months of(More)
Tumor angiogenesis, i.e. the development of neovascularisation in and around solid tumors, plays a key role in the local and distant growth of cancer and anti-angiogenic treatments are now established strategies to treat cancer patients. Specific inhibitors of angiogenesis such as bevacizumab or receptor tyrosine kinase inhibitors targeting VEGFR or PDGFR(More)
A mammalian model of genetically postponed aging would be an important tool to test not only different mechanisms of aging but also the predictive value of various biomarkers of the aging process. Under conventional conditions, the historical strains of the laboratory mouse produce their first litter between 9 and 13 weeks of age and have a median time of(More)