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Background: Cure is possible by resecting colorectal isolated liver metastases. In non-resectable isolated colorectal liver metastases (CRLM), regional chemotherapy has been advocated to optimize the disease control in the liver in order to improve the results of the alternative, systemic chemotherapy. The drugs are delivered by means of hepatic artery(More)
The free intracellular calcium concentration, [Ca2+]i, was studied in single myotubes using the fluorescent Ca2+ indicator fura-2. Myotubes cultured from satellite cells of small muscle specimens from Duchenne muscular dystrophy (DMD) patients were compared with human control myotubes and with myotubes cultured from MDX and control mouse muscle satellite(More)
BACKGROUND AND OBJECTIVES 5-Aminolevulinic acid (ALA) increases the intracellular accumulation of endogenous protoporphyrin IX in colon cancer. Protoporphyrin IX itself is a potential photosensitizer that can be used for laser light-induced fluorescence diagnosis. The aim of this study was to detect cancer in the rat colon before macroscopic visibility. (More)
OBJECTIVE Severe blunt chest trauma in humans is associated with high mortality rates. Whereas lung tissue damage and lung inflammation after blunt chest trauma have extensively been investigated, the traumatic and posttraumatic effects on the heart remain poorly understood. Therefore, the purpose of this study was to define cardiac injury patterns in an(More)
  • Miriam Kalbitz, S Schwarz, +13 authors F Hildebrand
  • Scientific reports
  • 2017
The purpose of this study was to define the relationship between cardiac depression and morphological and immunological alterations in cardiac tissue after multiple trauma. However, the mechanistic basis of depressed cardiac function after trauma is still elusive. In a porcine polytrauma model including blunt chest trauma, liver laceration, femur fracture(More)
CONTEXT Chronic low back pain (LBP) has been reported with a high incidence in elite rowers. It results in less effective training, long interruptions in training, and a drop in performance. OBJECTIVE The authors hypothesized that exercise-induced LBP in rowers is caused by a chronic functional compartment syndrome (CFCS) of the multifidus muscle. (More)
Background: NSC-631570 (Ukrain) is a semisynthetic compound of thiophosphoric acid and the alkaloid chelidonine from the plant Chelidonium majus. It has been used in complementary herbal medicine for more than 20 years for the treatment of benign and malignant tumors. Patients/methods: Between August 1999 and June 2001, 90 patients with histologically(More)
The incidence of cardiac injury in immediate fatalities after blunt trauma remains underestimated, and reliable diagnostic strategies are still missing. Furthermore, clinical data concerning heart-specific troponin serum levels, injury severity score (ISS), catecholamine treatment and survival of patients on admission to the hospital have rarely been(More)
Die Behandlung periprothetischer Femurfrakturen (PPF) ist mit einer erheblichen Komplikationsrate behaftet. Im Vergleich zu konventionellen Implantaten erlauben winkelstabile Plattensysteme eine stabile Fixation bei geringer Kompromittierung der Blutversorgung. Ziel war die Evaluation der Behandlungsergebnisse mit einem winkelstabilen Plattensystem(More)
OBJECTIVE Since the developments in systemic chemotherapy of metastasized colorectal cancer have not resulted in substantial gains in survival times, we wished to improve the course of isolated nonresectable colorectal liver metastases (CPLM) by hepatic arterial infusion treatment. BACKGROUND Patients (pts) with CRLM have a worse fate than those pts whose(More)