Jochen Küpper

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Increased poly(ADP-ribosyl)ation in intact cells by cisplatin treatment.

Alexander Bürkle, G. Chen, Jochen Küpper, Kai Grube, W. J. Zeller
Carcinogenesis
1993

Cisplatin (DDP) is a clinically important antitumor drug that induces the formation of DNA-DNA and DNA-protein crosslinks. We have studied whether poly(ADP-ribosyl)ation, a post-translational… (More)

trans-dominant inhibition of poly(ADP-ribosyl)ation sensitizes cells against gamma-irradiation and N-methyl-N'-nitro-N-nitrosoguanidine but does not limit DNA replication of a polyomavirus replicon.

Jochen Küpper, M. Mueller, +4 authors Alexander Bürkle
Molecular and cellular biology
1995

Poly(ADP-ribosyl)ation is a posttranslational modification of nuclear proteins catalyzed by poly(ADP-ribose) polymerase (PARP; EC 2.4.2.30), with NAD+ serving as the substrate. PARP is strongly… (More)

Negative regulation of alkylation-induced sister-chromatid exchange by poly(ADP-ribose) polymerase-1 activity.

R. Meyer, M. Müller, Sascha Beneke, Jochen Küpper, Alexander Bürkle
International journal of cancer
2000

One of the earliest responses to DNA damage in eukaryotic cells is activation of poly(ADP-ribose) polymerase-1 (PARP-1), a DNA strand break-dependent nuclear enzyme which covalently modifies proteins… (More)

Direct stimulation of poly(ADP ribose) polymerase in permeabilized cells by double-stranded DNA oligomers.

Kai Grube, Jochen Küpper, Alexander Bürkle
Analytical biochemistry
1991

Poly(ADP ribosyl)ation, a post-translational modification of nuclear proteins catalyzed by poly (ADP ribose) polymerase, is an immediate response of most eukaryotic cells to DNA strand breaks and has… (More)

DNA excision repair and DNA damage-induced apoptosis are linked to Poly(ADP-ribosyl)ation but have different requirements for p53.

Ralt Beneke, Caroline Geisen, +4 authors Tarik Möröy
Molecular and cellular biology
2000

Poly(ADP-ribose) polymerase (PARP) is a DNA binding zinc finger protein that catalyzes the transfer of ADP-ribose residues from NAD(+) to itself and different chromatin constituents, forming branched… (More)

Laser-induced alignment and orientation of quantum-state-selected large molecules.

Lotte Holmegaard, Jens H. Nielsen, +4 authors Gerard Meijer
Physical review letters
2009

A strong inhomogeneous static electric field is used to spatially disperse a supersonic beam of polar molecules, according to their quantum state. We show that the molecules residing in the… (More)

Imaging charge transfer in iodomethane upon x-ray photoabsorption.

Benjamin Erk, Rebecca Boll, +18 authors Artem Rudenko
Science
2014

Studies of charge transfer are often hampered by difficulties in determining the charge localization at a given time. Here, we used ultrashort x-ray free-electron laser pulses to image charge… (More)

Functional overexpression of human poly(ADP-ribose) polymerase in transfected rat tumor cells.

Frithjof Bernges, Alexander Bürkle, Jochen Küpper, W. J. Zeller
Carcinogenesis
1997

Poly(ADP-ribose) polymerase (PARP, EC 2.4.2.30) is a nuclear enzyme possibly involved in DNA base excision repair. The presence of single- or double-strand breaks in DNA stimulates this enzyme to… (More)

Dynamics of neutral molecules stored in a ring

Floris Crompvoets, Hendrick L. Bethlem, Jochen Küpper, André J. A. van Roij, Gerard Meijer
2004

Floris M. H. Crompvoets, Hendrick L. Bethlem, Jochen Küpper, André J. A. van Roij, and Gerard Meijer Fritz-Haber-Institut der Max-Planck-Gesellschaft, Faradayweg 4-6, D-14195 Berlin, Germany;… (More)

Quantum-state selection, alignment, and orientation of large molecules using static electric and laser fields.

Frank Filsinger, Jochen Küpper, +5 authors Henrik Stapelfeldt
The Journal of chemical physics
2009

Supersonic beams of polar molecules are deflected using inhomogeneous electric fields. The quantum-state selectivity of the deflection is used to spatially separate molecules according to their… (More)

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