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  • I Caramalho, Thiago Lopes-Carvalho, Dominique Ostler, Santiago Zelenay, Matthias Haury, Jocelyne Demengeot
  • Medicine, Biology
  • The Journal of experimental medicine
  • 2003 (First Publication: 17 February 2003)
  • Regulatory CD4 T cells (Treg) control inflammatory reactions to commensal bacteria and opportunist pathogens. Activation of Treg functions during these processes might be mediated by host-derivedContinue Reading
  • João H Duarte, Santiago Zelenay, Marie-Louise Bergman, Ana C Martins, Jocelyne Demengeot
  • Medicine, Biology
  • European journal of immunology
  • 2009 (First Publication: 1 April 2009)
  • Induction of Forkhead-box p3 (Foxp3) expression in developing T cells upon peptide-MHC encountering has been proposed to define a lineage of committed Treg cells. However, sustained expression ofContinue Reading
  • Shohei Hori, Matthias Haury, António Coutinho, Jocelyne Demengeot
  • Medicine, Biology
  • Proceedings of the National Academy of Sciences…
  • 2002 (First Publication: 28 May 2002)
  • CD25+4+ regulatory T cells (Treg) play an indispensable role in preventing autoimmunity. Little is known, however, about the antigen specificities required for their development and effectorContinue Reading
  • Santiago Zelenay, Thiago Lopes-Carvalho, I Caramalho, Maria Francisca Moraes-Fontes, Manuel Rebelo, Jocelyne Demengeot
  • Medicine, Biology
  • Proceedings of the National Academy of Sciences…
  • 2005 (First Publication: 15 March 2005)
  • Expression of the IL-2 receptor alpha chain (CD25) by peripheral CD4 T cells follows cellular activation. However, CD25 expression by CD4 cells is widely used as a marker to identify regulatory TContinue Reading
  • Margarida Albuquerque Almeida Santos, Leonor Morais Sarmento, +8 authors Jocelyne Demengeot
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences
  • 2007 (First Publication: 25 September 2007)
  • Notch signaling regulates B and T lymphocyte development and T cell effector class decision. In this work, we tested whether Notch activity affects mature B cell activation and differentiation toContinue Reading
  • Ricardo Sousa Paiva, Andreia C. Lino, +4 authors Jocelyne Demengeot
  • Medicine, Biology
  • Proceedings of the National Academy of Sciences
  • 2013 (First Publication: 1 April 2013)
  • Most Forkhead box P3+ (Foxp3+) CD4 regulatory T cell (Treg) precursors are newly formed thymocytes that acquire Foxp3 expression on antigen encounter in the thymus. Differentiation of Treg, however,Continue Reading