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Chronic pain is associated with a range of other problems, including disturbed sleep, depression, anxiety, fatigue, reduced quality of life, and an inability to work or socialise. We investigated whether good symptom control of pain (using definitions of moderate and substantial benefit) is associated with improvement in other symptoms. Individual patient(More)
We defined response in acute pain trials according to percentage of maximum possible efficacy. Minimum efficacy criteria (MEC) of 0%, or at least 15%, 30%, 50%, and 70% pain relief were used to examine stability over time using total pain relief and summed pain intensity difference (SPID), sex differences, and sensitivity. We used individual patient data(More)
BACKGROUND Clinical trials in chronic pain often collect information about interference with work as answers to component questions of commonly used questionnaires but these data are not normally analysed separately. METHODS We performed a meta-analysis of individual patient data from four large trials of pregabalin for fibromyalgia lasting 8-14 weeks. We(More)
Spreadsheets often need changing in ways made tedious and risky by Excel. For example: simultaneously altering many tables' size, orientation, and position; inserting cross-tabulations; moving data between sheets; splitting and merging sheets. A safer, faster restructuring tool is, we claim, Excelsior. The result of a research project into reducing(More)
BACKGROUND Population mean changes are difficult to use in clinical practice. Responder analysis may be better, but needs validating for level of response and treatment duration. A consensus group has defined what constitutes minimal, moderate, and substantial benefit based on pain intensity and Patient Global Impression of Change scores. METHODS We(More)
The effect of a therapeutically administered high calorie diet in a severely malnourished patient is discussed in this case report. In patients with advanced head and neck cancer prolonged periods of malnutrition prior to admission are frequently encountered. This case report highlights the need to constantly monitor the electrolyte and vitamin levels(More)
We have developed the Model Master (MM) language for describing spreadsheets, and tools for converting MM programs to and from spreadsheets. The MM decompiler translates a spreadsheet into an MM program which gives a concise summary of its calculations, layout, and styling. This is valuable when trying to understand spreadsheets one has not seen before, and(More)