Joaquim Teixeira

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The peroxisome proliferator-activated receptors (PPARs) are important molecular targets for the development of drugs for the treatment of human metabolic diseases, inflammation, and cancer. They are known to be activated by a variety of structurally diverse compounds. Using a structure-based drug design approach, we designed and synthesized a series of(More)
Acknowledgements I would like to take this space to express my gratitude to the people who made this thesis possible. I express my deepest gratitude to my supervisor professor Dr. Zita A. Vale for all the provided means she gave me to execute this thesis and all the positive energy, productive discussions and exceptional assistance. I greatly appreciate her(More)
We report the first case of a recurrent malignant subdural effusion that was treated with whole-brain radiation therapy. A 72-year-old man presented with headaches and de novo left central facial palsy and right upper extremity weakness. His past medical history was remarkable for a prostatic adenocarcinoma diagnosed in 1999 (T4N0M0) with no metastatic(More)
BACKGROUND Myeloid sarcoma (MS) is a malignant tumor that usually occurs concomitantly with or following acute myeloid leukemia (AML). Cavernomas are benign congenital malformations that are unusual in the spine and exceedingly rare in pure extradural locations. CASE DESCRIPTION We report a 73-year-old female with a previous medical history of AML in(More)
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