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This work describes the syntheses and antitumoral properties of five prenyl compounds from which antiproliferative activities were predicted by using the TOPS-MODE approach, a computational method for drug design. The syntheses of 2-(3-methylbut-2-enyloxy)acetophenone (2), 2-hydroxy-5-(3-methylbut-2-enyl)acetophenone (3),(More)
A number of human activities exhibit a bursty pattern, namely periods of very high activity that are followed by rest periods. Records of this process generate time series of events whose inter-event times follow a probability distribution that displays a fat tail. The grounds for such phenomenon are not yet clearly understood. In the present work we use(More)
Proximate composition (ash, moisture, total protein, and fat contents) and fatty acid profile of Balistes capriscus (grey triggerfish) were assessed over a 6-months period (April to September, 2011) in animals captured along the coast of Peniche (Portugal). High protein (18.9% to 21.4%) and low lipid (0.5% to 0.8%) contents were determined. The highest(More)
The voluntary process of Wikipedia edition provides an environment where the outcome is clearly a collective product of interactions involving a large number of people. We propose a simple agent-based model, developed from real data, to reproduce the collaborative process of Wikipedia edition. With a small number of simple ingredients, our model mimics(More)
A number of human activities exhibit a bursty pattern, namely periods of very high activity that are followed by rest periods. Records of these processes generate time series of events whose inter-event times follow a probability distribution that displays a fat tail. The grounds for such phenomenon are not yet clearly understood. In the present work we use(More)
This work presents the results of a study on the variation of the chemical composition of Pyrenean oak (Quercus pyrenaica Willd.) heartwood among different sites and its relationship with the soil chemical characteristics. The chemical characteristics of the heartwood are quantified in terms of proximate and ultimate analysis, calorific value and ash(More)
Motivated by the development and deployment of large-scale dynamical systems, often composed of geographically distributed smaller subsystems, we address the problem of verifying their controllability in a distributed manner. In this work we study controllability in the structural system theoretic sense, structural controllability. In other words, instead(More)
Aim: The main purpose of this study was to adapt the Restraint Scale (RS) to Portuguese and examine its psychometric properties, specifically its construct validity. Method: In this study, 238 normal-weight adults (82% women; Mean age = 36.6, SD = 15.0) participated in an online survey containing measures of Restraint Scale, Three Factor Eating(More)
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