Learn More
We study the analysis of a joint association between a genetic marker with both binary (case-control) and quantitative (continuous) traits, where the quantitative trait values are only available for the cases due to data sharing and outcome-dependent sampling. Data sharing becomes common in genetic association studies, and the outcome-dependent sampling is(More)
MOTIVATION Integrative mathematical and statistical models of cardiac anatomy and physiology can play a vital role in understanding cardiac disease phenotype and planning therapeutic strategies. However, the accuracy and predictive power of such models is dependent upon the breadth and depth of noninvasive imaging datasets. The Cardiac Atlas Project (CAP)(More)
Left ventricular remodeling during the development of heart failure is a strong predictor of cardiovascular mortality. However, methods to objectively quantify remodeling-associated shape changes are not routinely available but may be possible with new computational anatomy tools. In this study, we analyzed and compared multi-detector computed tomographic(More)
Proton MR spectroscopy ((1)H-MRS) has been used for in vivo quantification of intracellular triglycerides within the sarcolemma. The purpose of this study was to assess whether breath-hold dual-echo in- and out-of-phase MRI at 3.0 T can quantify the fat content of the myocardium. Biases, including T(1), T*(2), and noise, that confound the calculation of the(More)
OBJECTIVE To determine whether middle-aged and older individuals with impaired fasting glucose (IFG), but no clinical evidence of cardiovascular disease, exhibit abnormal changes in proximal thoracic aortic stiffness or left ventricular (LV) mass when compared with healthy counterparts. RESEARCH DESIGN AND METHODS From the Multi-Ethnic Study of(More)
OBJECTIVE Examine whether there are independent influences of a greater degree of adiposity and longer duration of obesity on cardiac structure and function. METHODS Participants of CARDIA were 18-30 years when they underwent a baseline examination in 1985-86. Seven follow-up examinations were conducted every 2-5 years. RESULTS Among 2,547 participants(More)
BACKGROUND The aim of this study is to determine the test-retest reliability of the measurement of regional myocardial function by cardiovascular magnetic resonance (CMR) tagging using spatial modulation of magnetization. METHODS Twenty-five participants underwent CMR tagging twice over 12 ± 7 days. To assess the role of slice orientation on strain(More)
BACKGROUND Current smoking is associated with type 2 diabetes mellitus and impaired glucose tolerance but its association with the metabolic syndrome (metS), particularly with sufficiently sampled African American representation, has not been clearly established. OBJECTIVE To assess whether a) metS is associated with smoking; b) any increased risk of metS(More)
PURPOSE Serotonin and the serotonin transporter have been implicated in the development of pulmonary hypertension (PH). Selective serotonin reuptake inhibitors (SSRIs) may have a role in PH treatment, but the effects of SSRI use on right ventricular (RV) structure and function are unknown. We hypothesized that SSRI use would be associated with RV morphology(More)
BACKGROUND Delayed post-contrast magnetic resonance (MR) imaging involves suppression of signal from myocardium using inversion times (TI) between 150-225 ms, when the myocardium appears dark and fibrotic scar appears bright. We noticed that at a TI optimized for signal suppression of the left ventricle (LV), the right ventricle (RV) appeared brighter. (More)