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OBJECTIVE To evaluate sperm DNA fragmentation and semen parameters to diagnose male factor infertility and predict pregnancy after IVF. DESIGN Prospective study. SETTING Academic research laboratory. PATIENT(S) Seventy-five couples undergoing IVF and 28 fertile donors. INTERVENTION(S) Sperm DNA fragmentation was measured by the alkaline Comet assay… (More)
BACKGROUND Sperm DNA damage shows great promise as a biomarker of infertility. The study aim is to determine the usefulness of DNA fragmentation (DF), including modified bases (MB), to predict assisted reproduction treatment (ART) outcomes. METHODS DF in 360 couples (230 IVF and 130 ICSI) was measured by the alkaline Comet assay in semen and in sperm… (More)
T he Pan American Health Organization (PAHO) has adopted a new policy on research for health. This policy aims to ensure that PAHO remains true to being a knowledge-based organization, that strong and sustainable national health research systems are found in every country in the Americas, and that research evidence constitutes a cornerstone of all… (More)
Report from the Ministerial Summit on Health Research: identify challenges, inform actions, correct inequities.
It is now almost thirty years since the birth of Louise Brown, the first baby to be born as a result of in-vitro fertilization (IVF). IVF was developed to overcome the problem of blocked fallopian tubes. However, with many ensuing modifications it is now used to treat infertility of almost any aetiology, including that of couples whose failure to conceive… (More)
This publication may be reviewed, abstracted or reproduced in part when fully referenced, but may not be sold or used for commercial purposes. various drafts of this report.
OBJECTIVE Research indicates that parents of twins have poorer psychosocial outcomes than parents of singletons. Parents who have conceived using assisted reproductive technology (ART) have been found to be at higher risk of negative psychosocial outcomes compared to parents who have conceived spontaneously. The current study aimed to model the factors… (More)
The burden placed on a hospital by the presence of an assisted conception unit has been emphasised only in terms of its impact on neonatal services. This paper examines the previously neglected subject of the gynaecological workload generated by a tertiary fertility centre that provides treatments by assisted conception. As many IVF units operate… (More)