Joanne McManus

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OBJECTIVE To evaluate sperm DNA fragmentation and semen parameters to diagnose male factor infertility and predict pregnancy after IVF. DESIGN Prospective study. SETTING Academic research laboratory. PATIENT(S) Seventy-five couples undergoing IVF and 28 fertile donors. INTERVENTION(S) Sperm DNA fragmentation was measured by the alkaline Comet assay(More)
BACKGROUND Sperm DNA damage shows great promise as a biomarker of infertility. The study aim is to determine the usefulness of DNA fragmentation (DF), including modified bases (MB), to predict assisted reproduction treatment (ART) outcomes. METHODS DF in 360 couples (230 IVF and 130 ICSI) was measured by the alkaline Comet assay in semen and in sperm(More)
Sperm DNA damage has a negative impact on pregnancy rates following assisted reproduction treatment (ART). The aim of the present study was to examine the relationship between sperm DNA fragmentation and live-birth rates after IVF and intracytoplasmic sperm injection (ICSI). The alkaline Comet assay was employed to measure sperm DNA fragmentation in native(More)
There is still disagreement concerning the optimal procedure for the diagnosis of milder degrees of hyperglycaemia in pregnancy. We have compared the results of a 75 g oral glucose tolerance test (OGTT) and a standardised breakfast test performed one week apart in 102 non-diabetic women with a singleton pregnancy. There was poor correlation between the two(More)
Although this is a factual book it contains personal stories of patients, scientists and clinicians involved in the development of IVF. It features a rather eccentric American Gynaecologist, Landrum Shettles, whose early attempts at IVF were obstructed by a senior colleague. On the receiving end of his work was a patient, Doris Del-Zio, who would have done(More)
The burden placed on a hospital by the presence of an assisted conception unit has been emphasised only in terms of its impact on neonatal services. This paper examines the previously neglected subject of the gynaecological workload generated by a tertiary fertility centre that provides treatments by assisted conception. As many IVF units operate(More)
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