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Contingent Negative Variation (CNV) in anticipation of phobic and neutral slide material was recorded in Acquisition of a learned association between tone pitch and slide type, and in Extinction (following removal of slide presentation). In phobic volunteers, no clear CNV differentiation between 'phobic' and control condition was apparent in either(More)
Immunoglobulin class switch recombination (Ig CSR) involves DNA double strand breaks (DSBs) at recombining switch regions and repair of these breaks by nonhomologous end-joining. Because the protein kinase ataxia telengiectasia (AT) mutated (ATM) plays a critical role in DSB repair and AT patients show abnormalities of Ig isotype expression, we assessed the(More)
OBJECTIVE To examine if different violent offending behaviours are associated with different clinical and neuroimaging profiles. METHOD Thirty-nine schizophrenic and schizoaffective offenders from a maximum security mental hospital-20 repetitive violent offenders (RVOs) and 19 non-repetitive violent offenders (NRVOs)-were selected for clinical and(More)
There have been recent suggestions that the amygdala may be involved in the development or mediation of 'theory of mind'. We report a patient, B.M., with early or congenital left amygdala damage who, by adulthood, had received the psychiatric diagnoses of schizophrenia and Asperger's syndrome. We conducted a series of experimental investigations to(More)
BACKGROUND The ability to travel mentally through time sets humans apart from many other species, yet little is known about this core cognitive capacity. In particular, what shapes the passage of the mind's journey through time? Guided by the viewpoint that higher cognitive activity can have a sensory-motor grounding, we explored the possibility that mental(More)
BACKGROUND Twenty-six young men admitted to an Accident and Emergency Department for observation following a minor closed head injury (post-traumatic amnesia (PTA) less than 12 hours) were investigated within 24 hours of admission (day 0) and followed up at 10 days, 6 weeks and 1 year after the trauma. METHOD Investigations at day 0 included physical(More)
The amplitude of the P300 component of auditory evoked responses was found to be depressed by benzodiazepine sedation and was subsequently used to monitor the recovery of volunteers sedated with midazolam. The amplitude of the evoked responses was found to be highly correlated with blood midazolam levels but to be no more sensitive than standard psychomotor(More)
Magnetic field tomography is a technique for extracting 3-dimensional estimates of current density in the brain, from non-contact, non-invasive measurements of the magnetic field generated by the brain. It allows visualisation of both cortical and subcortical focal activation patterns at millisecond intervals, and the relative time difference between active(More)
The temporal coordination of interpersonal behavior is a foundation for effective joint action with synchronized movement moderating core components of person perception and social exchange. Questions remain, however, regarding the precise conditions under which interpersonal synchrony emerges. In particular, with whom do people reliably synchronize their(More)
The FDG PET brain scans from 31 offenders with schizophrenia and schizoaffective disorder from a maximum security mental hospital were compared with those of normal controls (N = 6) in terms of relative FDG uptake in a range of regions covering frontal and temporal regions. The patient sample was divided into those who had a history of repetitive violent(More)