Joanne M Faysal

Learn More
Abnormally suppressed levels of cyclin-dependent kinase inhibitors (CKIs) are associated with aggressive androgen-independent prostate cancer and contribute to uncontrolled proliferation. The androgen-independent human prostate cancer cell lines, LNCaP-104R1, ALVA31 and PC-3, express low levels of the CKI, p21CIP1, compared to the less-malignant,(More)
Prostate cancer invariably recurs after androgen deprivation therapy. Growth of this recurrent/androgen-independent form of prostate cancer may be due to increased androgen receptor (AR) transcriptional activity in the absence of androgen. This ligand-independent AR activation is promoted by some growth factors but the mechanism is not well understood.(More)
INTRODUCTION. Most prostate cancer initially displays androgen dependency for growth and survival such that tumor growth is inhibited by androgen deprivation. However, prostate cancer invariably progresses to an androgenindependent state marked by growth that is unaffected by hormonal manipulation. Abnormally suppressed levels of cyclin-dependent kinase(More)
BACKGROUND In 2007, the Agency for Healthcare Research and Quality(AHRQ) published a systematic review on the comparative effectiveness of oral medications for type 2 diabetes. The review included studies on the benefits and risks of oral medications used for achieving glycemic control in patients with type 2 diabetes. AHRQ published an updated review in(More)
  • 1