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Interviews were conducted with 303 men to determine aspects of work history and working environment that are related to low-back pain. Respondents included no pain, moderate pain, and severe pain samples. Data were obtained for 150 variables including task frequencies, weights lifted, lifting postures, type of floor surface, type of chair support, pushing,(More)
This study investigates the relationship between manual muscle test scores (MMT) and quantitative isometric strength measurements (QIS). It also evaluates the implications of that relationship for design of therapeutic trials. Extension and flexion strength at the elbows, hips, and knees of 21 neuromuscular disease patients were tested a total of 26 times(More)
AIM This study models the cost-effectiveness of brief advice (BA) in primary care for physical activity (PA) addressing the limitations in the current limited economic literature through the use of a time-based modelling approach. METHODS A Markov model was used to compare the lifetime costs and outcomes of a cohort of 100 000 people exposed to BA versus(More)
BACKGROUND Increased mortality rates associated with weekend hospital admission (the so-called weekend effect) have been attributed to suboptimum staffing levels of specialist consultants. However, evidence for a causal association is elusive, and the magnitude of the weekend specialist deficit remains unquantified. This uncertainty could hamper efforts by(More)
BACKGROUND Published cost-effectiveness estimates can vary considerably, both within and between countries. Despite extensive discussion, little is known empirically about factors relating to these variations. OBJECTIVES To use multilevel statistical modeling to integrate cost-effectiveness estimates from published economic evaluations to investigate(More)
BACKGROUND The EQ-5D, a generic health status questionnaire that is widely used in health economic evaluation, was recently expanded to the EQ-5D-5L to address criticisms of unresponsiveness and ceiling effect. AIMS To describe the validity, responsiveness and minimum important difference of the EQ-5D-5L in COPD. METHODS Study 1: The validity of the(More)
BACKGROUND Although many studies have identified public preferences for prioritising health care interventions based on characteristics of recipient or care, very few of them have examined the reasons for the stated preferences. We conducted an on-line person trade-off (PTO) study (N=1030) to investigate whether the public attach a premium to the avoidance(More)
OBJECTIVES The aim of this study is to describe and illustrate a method to obtain early estimates of the effectiveness of a new version of a medical device. METHODS In the absence of empirical data, expert opinion may be elicited on the expected difference between the conventional and modified devices. Bayesian Mixed Treatment Comparison (MTC)(More)
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