Joanne J. Carter

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PURPOSE To determine the maximum tolerated dose, dose-limiting toxicity, pharmacokinetics, and preliminary therapeutic activity profile of CHR-2797 (tosedostat), a novel, orally bioavailable inhibitor of the M1 family of aminopeptidases with antiproliferative and antiangiogenic activity in vitro. EXPERIMENTAL DESIGN A phase I study of accelerated(More)
The purpose of this study was to examine the effects of a 2-hour laboratory challenge on heart rate, blood pressure, catecholamines, and cortisol; and investigate the contribution of the physical act of speaking on both neuroendocrine and cardiovascular measures. Using a within-subjects design, 14 subjects were tested individually during two separate(More)
The atlantoaxial joints of a patient with lateral subluxation of the atlas were studied post mortem by dissection. There was severe erosion of the left lateral atlantoaxial joint and an asymmetrical erosion of the cartilages of the median atlantoaxial joint which prevented reduction of the lateral subluxation. The atlantoaxial ligaments were remarkably(More)
Sixty-five patients referred for Tc-99m HMPAO SPECT brain perfusion studies had measurements of global Tc-99m HMPAO retention after injection at rest and after acetazolamide pretreatment. Acetazolamide produced relative changes in Tc-99m HMPAO retention similar to those previously reported with Xe-133 regional cerebral blood flow (rCBF) measurements. This(More)
The efficacy of nebulized glycopyrrolate compared with metaproterenol was evaluated in 46 patients with acute asthma. In a double-blinded, randomized fashion, patients received, as sole therapy, either 2 mg of glycopyrrolate or 15 mg of metaproterenol every 2 h over a 6-h study period. Of the 35 patients completing the study, analysis of variance(More)
Sudden unilateral hearing loss may result from etiologies affecting cochlea, eighth nerve, or more central auditory tracts. Two case studies are presented in which the measurement of otoacoustic emissions helped rule out outer hair cell cochlear pathology. In both cases, the final diagnosis was sudden unilateral hearing loss associated with multiple(More)
Although inspiratory resistive loading (IRL) reduces the ventilatory response to CO2 (VE/PCO2) and increases the sensation of inspiratory effort (IES), there are few data about the converse situation: whether CO2 responsiveness influences sustained load compensation and whether awareness of respiratory effort modifies this behavior. We studied 12 normal men(More)
VEGF inhibitors, including receptor tyrosine kinase inhibitors, are used as adjunct therapies in a number of cancer treatments. An emerging issue with these drugs is that most cause hypertension. To gain insight into the physiological mechanisms involved, we evaluated their regional hemodynamic effects in conscious rats. Male Sprague Dawley rats (350-450 g)(More)
1. To examine the effects of sustained resistive loading on the relationship between inspiratory effort sensation and respiratory drive (P0.1) and to determine if the change in CO2 responsiveness after sustained loading is accompanied by altered effort perception, hypercapnic responses were measured before, immediately after and 15 min after sustained(More)
BACKGROUND AND PURPOSE Receptor tyrosine kinase inhibitors (RTKIs) targeted at VEGF receptor 2 (VEGFR2) have proved to be attractive approaches to cancer therapy based on their ability to reduce angiogenesis. Here we have undertaken a quantitative analysis of the interaction of RTKIs and two VEGF splice variants, VEGF(165)a and VEGF(165)b, with VEGFR2 by(More)