Joanne Broadhead

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An understanding of the properties of water in hydrated saccharides and saccharide derivatives is relevant to a number of pharmaceutical processes, including wet granulation. This study uses a range of physical measurement techniques [viz. nuclear magnetic resonance spectroscopy (NMR), dielectric relaxation spectroscopy (DRS), near infrared spectroscopy(More)
We have previously developed a spray dried formulation of a model protein (beta-galactosidase) of a size suitable for evaluation in dry powder inhaler devices. In this study, we wished to evaluate the roles of various methods available for the laboratory testing of dry powders for inhalation (cascade impactor, twin impinger, aerodynamic time of flight and(More)
The objective of this study was to evaluate the joint effects of various processing and formulation variables on the properties of spray-dried beta-galactosidase using statistically designed experiments. The key response variables evaluated were product yield, residual enzymatic activity, moisture content and particle size and appearance. The residual(More)
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