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On the basis of the recently published results of a clinical trial comparing 12 and 36 months of imatinib in adjuvant therapy for gastrointestinal stromal tumors (GISTs), which demonstrated clinical benefit of longer imatinib treatment in terms of delaying recurrences and improving overall survival, both the US Food and Drug Administration and the European… (More)
Soft tissue and bone sarcomas comprise a heterogeneous group of mesenchymal tumors that include roughly 130 distinct diagnostic entities. Many of them are exceptionally rare, with only few cases diagnosed worldwide each year. Development of novel targeted treatment in this group of tumors is of special importance since many sarcoma subtypes are resistant to… (More)
A case is described of extensive, bleeding plano-epithelial carcinoma of back skin in burn scar in a 62-year-old man. The lesion was extensively excised with partial resection of Th 12-L3 spinous processes with covering of the loss with a graft. During 15-month follow up no manifestations of disease recurrence were seen.