Joanna Manoranjan

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The ESX-1 secretion system plays a critical role in the virulence of M. tuberculosis and M. marinum, but the precise molecular and cellular mechanisms are not clearly defined. Virulent M. marinum is able to escape from the Mycobacterium-containing vacuole (MCV) into the host cell cytosol, polymerize actin, and spread from cell to cell. In this study, we(More)
The ESX-1 secretion system plays a critical role in the virulence of Mycobacterium tuberculosis and M. marinum. To date, three proteins are known to be secreted by ESX-1 and necessary for virulence, two of which are CFP-10 and ESAT-6. The ESX-1 secretion and the virulence mechanisms are not well understood. In this study, we have examined the M. marinum(More)
M. marinum naturally infects fish and amphibians and causes diseases in these animals with pathological features similar to the human disease caused by M. tuberculosis. At the genetic and biochemical levels, M. marinum is closely related to M. tuberculosis. Because of these and other properties of M. marinum (such as its fast growth rate and convenient(More)
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