Joanna Lipińska

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In autoimmune inflammatory diseases, including juvenile idiopathic arthritis (JIA), which leads to joint destruction, there is an imbalance between production of reactive oxygen species (ROS) and their neutralization which, as a consequence, leads to “oxidative stress.” The aim of the study was to assess the concentration of oxidative stress markers: nitric(More)
Anti-cyclic citrullinated peptide (anti-CCP) antibodies are considered to be a marker of rheumatoid arthritis (RA). However, limited and controversial reports concern this problem in children with juvenile idiopathic arthritis (JIA). Objective: To access the prevalence and diagnostic value of anti-CCP antibodies in children with JIA. Sera of 96 JIA children(More)
OBJECTIVE The aim of the study was to investigate whether determination of anticitrullinated protein antibodies (ACPA) provides predictive information on severity of disease course and joint destruction in children with juvenile idiopathic arthritis (JIA). METHODS Sera from 74 children with JIA were examined for ACPA using the ELISA test. To assess joint(More)
Takayasu’s arteritis (TA) rarely occurs in infants. There are only four reports on TA in children below 1 year of age, revealing diversity of its symptoms. We describe a 7-month-old female infant hospitalized for hectic fever, irritability, high acute phase indices, and coronary artery dilatations found on echocardiography, which suggested Kawasaki disease(More)
INTRODUCTION Antiphospholipid syndrome is a multisystem autoimmune disease characterized by arterial and/or venous thrombosis and persistent presence of antiphospholipid antibodies. It can be a primary disease or secondary when associated with other autoimmune diseases. CASE PRESENTATION We present a case of a 16-year-old Caucasian boy with a massive(More)
Lateral electrical surface stimulation is one of methods used in the therapy of the progressive form of idiopathic scoliosis (IS) in children and youth. However, there are data suggesting that this method may lead to serious adverse side effects, when used for a too long period of time per day. To clarify this issue, the present study was aimed at(More)
The aim of this experiment was to compare the role of renin-angiotensin and sympathetic nervous system in post-haemorrhagic mechanism of oxytocin release. Oxytocin content in venous dialysates was determined by radioimmunoassay. In control rats the release of oxytocin into dialysates did not change during whole experiment. The injection of captopril induced(More)
The aim of the present study was to compare the influence of the renin-angiotensin and sympathetic system in the process of post-haemorrhagic vasopressin release. A dialysis of the venous blood from the sella turcica region was performed in male rats under anaesthesia. The animals were divided into eight experimental groups: 1). control; 2). bleeding; 3).(More)
Vasopressin and oxytocin are neurohormones of the posterior pituitary lobe released not only into the blood, but also into cerebrospinal fluid (CSF). Posterior pituitary lobe has central and peripheral noradrenergic innervation; peripheral origins from superior cervical ganglia (SCG) (Alper et al. 1980; Saavedra 1986). It is known, that sympathetic nervous(More)
The main cellular source of reactive oxygen species (ROS) is mitochondrial respiratory chain and active NADPH responsible for "respiratory burst" of phagocytes. Whatsmore ROS are produced in endoplasmic reticulum, peroxisomes, with the participation of xanthine and endothelial oxidase and during autoxidation process of small molecules. Mitochondrial(More)