Joanna L Feltham

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Proteins of the rho subfamily of ras GTPases have been shown to be crucial components of pathways leading to cell growth and the establishment of cell polarity and mobility. Presented here is the solution structure of one such protein, Cdc42Hs, which provides insight into the structural basis for specificity of interactions between this protein and its(More)
(K d in the low micromolar range). As a first step, Chen and Sigler formed cocrystals of the SBP peptide and the isolated apical domain of GroEL (residues 191–336), and Molecular chaperones ensure that proteins achieve and solved this structure at high resolution (2.1 A ˚ , see Figure maintain their proper folds in the appropriate cellular 2a). They have(More)
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