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This article reveals a novel aspect in the regulation of synaptic connectivity in Drosophila. Reducing neural activity genetically or pharmacologically disrupts the normally precise embryonic and larval neuromuscular connections. In third instar larvae with mutations that affect sodium channel function or expression such as no action potential,(More)
The neuromuscular connections of Drosophila are ideally suited for studying synaptic function and development. Hypotheses about cell recognition can be tested in a simple array of pre- and postsynaptic elements. Drosophila muscle fibers are multiply innervated by individually identifiable motoneurons. The neurons express several synaptic cotransmitters,(More)
Synaptogenesis can be analyzed in a simple array of motoneurons and muscle fibers of the embryos and larvae of Drosophila melanogaster. Each abdominal hemisegment contains a stereotypic array of 30 muscle fibers. During middle to late embryogenesis, motoneurons exit the central nervous system to make precise synaptic connections with specific muscle fibers.(More)
This study assessed aphasic subjects' sensitivity to the given-new structure within simple paragraphs and the extent to which narrative discourse is facilitative of syntactic processing in the absence of semantic constraints. Subjects were divided into four groups along the dimensions of comprehension level and fluency. Stimulus items consisted of(More)
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