Joanna Hauser

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Activity-dependent neurotrophic factor (ADNF) is a glia-derived protein that is neuroprotective at femtomolar concentrations. A 14-amino acid peptide of ADNF (ADNF-14) has been reported that protects cultured neurons from multiple neurotoxins. Structure-activity relationships of peptides related to ADNF-14 now have been determined. A 9-amino acid core(More)
BACKGROUND There have been conflicting reports on whether the length polymorphism in the promoter of the serotonin transporter gene (5-HTTLPR) moderates the antidepressant effects of selective serotonin reuptake inhibitors (SSRIs). We hypothesised that the pharmacogenetic effect of 5-HTTLPR is modulated by gender, age and other variants in the serotonin(More)
BACKGROUND A number of scales are used to estimate the severity of depression. However, differences between self-report and clinician rating, multi-dimensionality and different weighting of individual symptoms in summed scores may affect the validity of measurement. In this study we examined and integrated the psychometric properties of three commonly used(More)
Recent molecular studies have implicated common alleles of small to moderate effect and rare alleles with larger effect sizes in the genetic architecture of schizophrenia (SCZ). It is expected that the reliable detection of risk variants with very small effect sizes can only be achieved through the recruitment of very large samples of patients and controls(More)
F. Abe, H. Akimoto, A. Akopian, M. G. Albrow, A. Amadon, S. R. Amendolia, D. Amidei, J. Antos, S. Aota, G. Apollinari, T. Arisawa, T. Asakawa, W. Ashmanskas, M. Atac, P. Azzi-Bacchetta, N. Bacchetta, S. Bagdasarov, M. W. Bailey, P. de Barbaro, A. Barbaro-Galtieri, V. E. Barnes, B. A. Barnett, M. Barone, G. Bauer, T. Baumann, F. Bedeschi, S. Behrends, S.(More)
OBJECTIVES The aim of the study was to test a possible association between the Val66Met polymorphism of the brain-derived neurotrophic factor (BDNF) gene and performance on a neurocognitive test, the Wisconsin Card Sorting Test (WCST), in bipolar patients. METHODS Fifty-four bipolar patients were studied, 18 male and 36 female, aged 18-72 (mean 46 years).(More)
Glycogen synthase kinase-3beta (GSK-3beta) has been implicated in the pathogenesis of major psychoses. In this paper, the T-50C polymorphism of the GSK-3beta gene has been studied in patients with schizophrenia (n=432), patients with bipolar disorder (n=416) and in a healthy control group (n=408). Consensus diagnosis by at least two psychiatrists was made(More)
The objective of the Genome-based Therapeutic Drugs for Depression study is to investigate the function of variations in genes encoding key proteins in serotonin, norepinephrine, neurotrophic and glucocorticoid signaling in determining the response to serotonin-reuptake-inhibiting and norepinephrine-reuptake-inhibiting antidepressants. A total of 116 single(More)
project approach in which the students are anxious to read the material because they have a project due. In contrast, this book appears more like a transcription of lecture notes in which there is a formal presentation of the material constituting the majority of the chapter, followed by some problems and codes for students to work.on. (The codes presented(More)
We have investigated the gene for dystrobrevin-binding protein 1 (DTNBP1), or dysbindin, which has been strongly suggested as a positional candidate gene for schizophrenia, in three samples of subjects with schizophrenia and unaffected control subjects of German (418 cases, 285 controls), Polish (294 cases, 113 controls), and Swedish (142 cases, 272(More)